Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study

被引:14
作者
Guan, Xu [2 ,3 ]
Wang, Yuliuming [1 ]
Hu, Hanqing [1 ]
Zhao, Zhixun [1 ]
Jiang, Zheng [2 ,3 ]
Liu, Zheng [2 ,3 ]
Chen, Yinggang [1 ]
Wang, Guiyu [1 ]
Wang, Xishan [1 ,2 ,3 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Colorectal Surg, Harbin, Heilongjiang, Peoples R China
[2] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept Colorectal Surg, Beijing, Peoples R China
[3] Peking Union Med Coll, Beijing, Peoples R China
来源
BMC CANCER | 2018年 / 18卷
关键词
Colon cancer; Young patient; Lymph node; SEER; COLORECTAL-CANCER; AGE; NUMBER; SURVIVAL; SURGERY; CARCINOMA; RETRIEVAL; PROGNOSIS; RESECTION; HARVEST;
D O I
10.1186/s12885-018-4428-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Currently, young colon cancer (CC) patients continue to increase and represent a heterogeneous patient group. The aim of this study was to explore the optimal minimum lymph node count after CC resection for young patients. Methods: We performed a comprehensive search of the Surveillance, Epidemiology, and End Results (SEER) database, 2360 CC patients aged from 20 to 40 were analyzed. X-tile was used to determine the optimal cut-off point of lymph node based on survival outcomes of young patients. The cancer specific survival (CSS) was estimated with Kaplan-Meier method, the Cox proportional hazards regression model was used to analyse independent prognostic factors and exact 95% confidence intervals (CIs). Results: Using X-tile analysis, 22-node measure was identified as the optimal choice for CC patients aged <40. The 5 year CSS were 85.8% and 80.9% for patients examining >= 22 nodes and < 22 nodes. Furthermore, we identified that examining < 22 nodes was an independent adverse prognostic factor in patients aged <40. In addition, the revised 22-node measure could examine more positive nodes than the standard 12-node measure in young patients. Conclusions: for young colon cancer patients, the lymph node examination should be differently evaluated. We suggest that 22-node measure may be more suitable for CC patients aged <40. i Trial registration: Retrospectively registered.
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页数:7
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