The role of genomic imprinting in biology and disease: an expanding view

被引：308

作者：

Peters, Jo ^{[1
]}

机构：

[1] MRC, Mammalian Genet Unit, Didcot OX11 0RD, Oxon, England

来源：

NATURE REVIEWS GENETICS | 2014年 / 15卷 / 08期

基金：

英国医学研究理事会;

关键词：

XL-ALPHA-S; PRADER-WILLI-SYNDROME; MOUSE MODEL; GROWTH-RETARDATION; ANGELMAN-SYNDROME; MICE LACKING; POSTNATAL-GROWTH; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; PATERNAL DELETION;

D O I：

10.1038/nrg3766

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genomic imprinting is an epigenetic phenomenon that results in monoallelic gene expression according to parental origin. It has long been established that imprinted genes have major effects on development and placental biology before birth. More recently, it has become evident that imprinted genes also have important roles after birth. In this Review, I bring together studies of the effects of imprinted genes from the prenatal period onwards. Recent work on postnatal stages shows that imprinted genes influence an extraordinarily wide- ranging array of biological processes, the effects of which extend into adulthood, and play important parts in common diseases that range from obesity to psychiatric disorders.

引用

页码：517 / 530

页数：14

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