Gamma Band Light Stimulation in Human Case Studies: Groundwork for Potential Alzheimer's Disease Treatment

被引：59

作者：

Jones, Marggie ^{[1
,2
]}

McDermott, Barry ^{[1
,2
]}

Oliveira, Barbara Luz ^{[1
]}

O'Brien, Aoife ^{[3
]}

Coogan, Declan ^{[3
]}

Lang, Mark ^{[4
]}

Moriarty, Niamh ^{[5
]}

Dowd, Eilis ^{[5
]}

Leo Quinlan ^{[6
]}

Mc Ginley, Brian ^{[1
,7
,8
]}

Dunne, Eoghan ^{[1
,2
]}

Newell, David ^{[1
,2
]}

Porter, Emily ^{[1
,2
]}

Elahi, Muhammad Adnan ^{[1
,2
]}

O' Halloran, Martin ^{[1
,2
]}

Shahzad, Atif ^{[1
,2
]}

机构：

[1] Natl Univ Ireland Galway, Translat Med Device Lab, Galway, Ireland

[2] Natl Univ Ireland Galway, Sch Elect & Elect Engn, Galway, Ireland

[3] Natl Univ Ireland Galway, Sch Psychol, Galway, Ireland

[4] Natl Univ Ireland Galway, Sch Phys, Galway, Ireland

[5] Natl Univ Ireland Galway, Discipline Pharmacol, Galway, Ireland

[6] Natl Univ Ireland Galway, Discipline Physiol, Galway, Ireland

[7] Galway Mayo Inst Technol, Dept Comp Sci, Galway, Ireland

[8] Galway Mayo Inst Technol, Dept Appl Phys, Galway, Ireland

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 70卷 / 01期

基金：

欧洲研究理事会;

关键词：

40; Hz; Alzheimer's disease; gamma band; human study; light stimulus; MODULATED TONES; RESPONSES; PHASE; EEG; ACTIVATION; MANAGEMENT; ATTENTION; EPILEPSY; CORTEX;

D O I：

10.3233/JAD-190299

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: It is known that proteins associated with Alzheimer's disease (AD) pathogenesis are significantly reduced by 40 Hz entrainment in mice. If this were to translate to humans, verifying that such a light stimulus can induce a 40 Hz entrainment response in humans and harnessing insights from these case studies could be one step in the development of a multisensory device to prevent and treat AD. Objective: Verify the inducement of a 40 Hz response in the human brain by a 40 Hz light stimulus and obtain insights that could potentially aid in the development of a multisensory device for the prevention and treatment of AD. Methods: Electroencephalographic brain activity was recorded simultaneously with application of stimulus at different frequencies and intensities. Power spectral densities were analyzed. Results: Entrainment to visual stimuli occurred with the largest response at 40 Hz. The high intensity 40 Hz stimulus caused widespread entrainment. The number of electrodes demonstrating entrainment increased with increasing light intensity. Largest amplitudes for the high intensity 40 Hz stimulus were consistently found at the primary visual cortex. There was a harmonic effect at double the frequency for the 40 Hz stimulus. An eyes-open protocol caused more entrainment than an eyes-closed protocol. Conclusion: It was possible to induce widespread entrainment using a 40 Hz light stimulus in this sample cohort. Insights gleaned from these case studies could potentially aid in the development of a multisensory medical device to prevent and treat AD.

引用

页码：171 / 185

页数：15

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