Impact of NHC Ligand Conformation and Solvent Concentration on the Ruthenium-Catalyzed Ring-Closing Metathesis Reaction

被引：58

作者：

Gatti, Michele ^{[1
]}

Vieille-Petit, Ludovic ^{[1
]}

Luan, Xinjun ^{[1
]}

Mariz, Ronaldo ^{[1
]}

Drinkel, Emma ^{[1
]}

Linden, Anthony ^{[1
]}

Dorta, Reto ^{[1
]}

机构：

[1] Univ Zurich UZH, Inst Organ Chem, CH-8057 Zurich, Switzerland

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 27期

关键词：

HETEROCYCLIC CARBENE LIGANDS; OLEFIN METATHESIS; EFFICIENT; COMPLEXES; RELEVANT; RUTHENACYCLOBUTANE; SUBSTITUTION; DIENES;

D O I：

10.1021/ja903554v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two saturated N-heterocyclic carbene ligands with substituted naphthyl side chains were used for the preparation of Blechert-type ruthenium metathesis precatalysts. The resulting conformers of the complexes were separated and unambiguously assigned by Xray diffraction studies. All new complexes were compared in terms of activity to the original, SIMes-derived Blechert catalyst and were shown to be superior. A study on the impact of solvent concentration in RCM reactions using the most active of these new catalysts ultimately led to the ring closing of a variety of substrates at very low catalyst loadings.

引用

页码：9498 / +

页数：3

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