Noncovalent interaction-assisted polymeric micelles for controlled drug delivery

被引：161

作者：

Ding, Jianxun ^{[1
]}

Chen, Linghui ^{[2
]}

Xiao, Chunsheng ^{[1
]}

Chen, Li ^{[3
]}

Zhuang, Xiuli ^{[1
]}

Chen, Xuesi ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Peoples R China

[2] Jilin Univ, Sch Chem, Changchun 130012, Peoples R China

[3] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 77期

基金：

中国国家自然科学基金;

关键词：

BLOCK-COPOLYMER MICELLES; POLYION COMPLEX MICELLES; OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE); POLYLACTIDE/POLY(ETHYLENE GLYCOL) MICELLES; CONJUGATED BETA-CYCLODEXTRIN; HOST-GUEST INTERACTIONS; TRIBLOCK COPOLYMERS; BUILDING-BLOCKS; CO-DELIVERY; VITAMIN-E;

D O I：

10.1039/c4cc03153a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymeric micelles are one of the most promising nanovehicles for drug delivery. In addition to amphiphilicity, various individual or synergistic noncovalent interplays including strong hydrophobic, electrostatic, host-guest, hydrogen bonding, stereocomplex and coordination interactions have been recently employed to improve the physical stability of micelles, and even provide them with certain intelligences or bioactivities. Through the ingenious designs and precise preparations, many noncovalent-mediated micelles display great prospects in the realm of controlled drug delivery, and certain species have been promoted to clinical trials. The current review presents the diverse noncovalent interactions that are applied to enhance polymeric micelles as drug nanocarriers, and preliminarily discusses the future directions and perspectives of this field.

引用

页码：11274 / 11290

页数：17

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