Insulin action in the hypothalamus and dorsal vagal complex

被引：26

作者：

Abraham, Mona A. ^{[1
,2
,3
]}

Filippi, Beatrice M. ^{[1
,2
]}

Kang, Gil Myoung ^{[4
]}

Kim, Min-Seon ^{[4
]}

Lam, Tony K. T. ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Univ Hlth Network, Toronto Gen Res Inst, Toronto, ON, Canada

[2] Univ Hlth Network, Dept Med, Toronto, ON, Canada

[3] Univ Toronto, Dept Physiol, Toronto, ON, Canada

[4] Univ Ulsan, Asan Med Ctr, Coll Med, Seoul, South Korea

[5] Univ Toronto, Dept Med, Toronto, ON, Canada

[6] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5G 1L5, Canada

来源：

EXPERIMENTAL PHYSIOLOGY | 2014年 / 99卷 / 09期

基金：

加拿大健康研究院;

关键词：

K-ATP CHANNELS; REGULATE GLUCOSE-PRODUCTION; NUCLEUS-TRACTUS-SOLITARII; ENERGY-BALANCE; FOOD-INTAKE; ACTIVATION; NEURONS; BRAIN; RESISTANCE; RATS;

D O I：

10.1113/expphysiol.2014.079962

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Insulin resistance is a hallmark feature of type 2 diabetes and obesity. In addition to the classical view that insulin resistance in the liver, muscle and fat disrupts glucose homeostasis, studies in the past decade have illustrated that insulin resistance in the hypothalamus dysregulates hepatic glucose production and food intake, leading to type 2 diabetes and obesity. This invited review argues that in addition to the hypothalamus, insulin signalling in the dorsal vagal complex regulates hepatic glucose production and food intake. A thorough understanding of the physiological and pathophysiological mechanisms of insulin action in the hypothalamus and dorsal vagal complex is necessary in order to identify therapeutic targets for obesity and type 2 diabetes.

引用

页码：1104 / 1109

页数：6

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