Nucleosome Occupancy and Gene Regulation During Tumorigenesis

被引：6

作者：

Andreu-Vieyra, C. V. ^{[1
]}

Liang, G. ^{[1
]}

机构：

[1] Univ So Calif, Los Angeles, CA 90089 USA

来源：

EPIGENETIC ALTERATIONS IN ONCOGENESIS | 2013年 / 754卷

关键词：

CHROMATIN-REMODELING FACTOR; TUMOR-SUPPRESSOR GENE; SWI/SNF-RELATED COMPLEXES; LINEAGE LEUKEMIA ROLES; HISTONE VARIANT H2A.Z; SWI-SNF COMPLEX; DNA METHYLATION; PROMOTER METHYLATION; TET2; MUTATIONS; CELLULAR PROLIFERATION;

D O I：

10.1007/978-1-4419-9967-2_5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nucleosomes are the basic structural units of eukaryotic chromatin. In recent years, it has become evident that nucleosomes and their position, in concert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and gene expression in normal and cancer cells.

引用

收藏

页码：109 / 134

页数：26

相关论文

共 194 条

[1] Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia [J].

Agirre, Xabier ;

Vilas-Zornoza, Amaia ;

Jimenez-Velasco, Antonio ;

Ignacio Martin-Subero, Jose ;

Cordeu, Lucia ;

Garate, Leire ;

San Jose-Eneriz, Edurne ;

Abizanda, Gloria ;

Rodriguez-Otero, Paula ;

Fortes, Puri ;

Rifon, Jose ;

Bandres, Eva ;

Jose Calasanz, Maria ;

Martin, Vanesa ;

Heiniger, Anabel ;

Torres, Antonio ;

Siebert, Reiner ;

Roman-Gomez, Jose ;

Prosper, Felipe .

CANCER RESEARCH, 2009, 69 (10) :4443-4453

[2] Dynamic Nucleosome-Depleted Regions at Androgen Receptor Enhancers in the Absence of Ligand in Prostate Cancer Cells [J].

Andreu-Vieyra, Claudia ;

Lai, John ;

Berman, Benjamin P. ;

Frenkel, Baruch ;

Jia, Li ;

Jones, Peter A. ;

Coetzee, Gerhard A. .

MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (23) :4648-4662

[3] Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing [J].

Ansari, Khairul I. ;

Mandal, Subhrangsu S. .

FEBS JOURNAL, 2010, 277 (08) :1790-1804

[4] Distinct Genetic Alterations in Colorectal Cancer [J].

Ashktorab, Hassan ;

Schaeffer, Alejandro A. ;

Daremipouran, Mohammad ;

Smoot, Duane T. ;

Lee, Edward ;

Brim, Hassan .

PLOS ONE, 2010, 5 (01)

[5] Mutations of the TET2 and CBL genes: novel molecular markers in myeloid malignancies [J].

Bacher, Ulrike ;

Haferlach, Claudia ;

Schnittger, Susanne ;

Kohlmann, Alexander ;

Kern, Wolfgang ;

Haferlach, Torsten .

ANNALS OF HEMATOLOGY, 2010, 89 (07) :643-652

[6] CHD5 is a tumor suppressor at human 1p36 [J].

Bagchi, Anindya ;

Papazoglu, Cristian ;

Wu, Ying ;

Capurso, Daniel ;

Brodt, Michael ;

Francis, Dailia ;

Bredel, Markus ;

Vogel, Hannes ;

Mills, Alea A. .

CELL, 2007, 128 (03) :459-475

[7] Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis [J].

Balaguer, Francesc ;

Link, Alexander ;

Lozano, Juan Jose ;

Cuatrecasas, Miriam ;

Nagasaka, Takeshi ;

Boland, C. Richard ;

Goel, Ajay .

CANCER RESEARCH, 2010, 70 (16) :6609-6618

[8] Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma [J].

Balakrishnan, Asha ;

Bleeker, Fonnet E. ;

Lamba, Simona ;

Rodolfo, Monica ;

Daniotti, Maria ;

Scarpa, Aldo ;

van Tilborg, Angela A. ;

Leenstra, Sieger ;

Zanon, Carlo ;

Bardelli, Alberto .

CANCER RESEARCH, 2007, 67 (08) :3545-3550

[9]

Beà S, 2001, CANCER RES, V61, P2409

[10] Determinants and dynamics of genome accessibility [J].

Bell, Oliver ;

Tiwari, Vijay K. ;

Thomae, Nicolas H. ;

Schuebeler, Dirk .

NATURE REVIEWS GENETICS, 2011, 12 (08) :554-564

← 1 2 3 4 5 6 7 8 9 10 →