Risk of Newly Detected Infections and Cervical Abnormalities in Women Seropositive for Naturally Acquired Human Papillomavirus Type 16/18 Antibodies: Analysis of the Control Arm of PATRICIA

被引：47

作者：

Castellsague, Xavier ^{[1
]}

Naud, Paulo ^{[2
]}

Chow, Song-Nan ^{[3
]}

Wheeler, Cosette M. ^{[4
,5
]}

Germar, Maria Julieta V. ^{[6
]}

Lehtinen, Matti ^{[7
]}

Paavonen, Jorma ^{[8
]}

Jaisamrarn, Unnop ^{[9
]}

Garland, Suzanne M. ^{[10
,11
,12
]}

Salmeron, Jorge ^{[13
]}

Apter, Dan ^{[14
]}

Kitchener, Henry ^{[15
]}

Teixeira, Julio C. ^{[16
]}

Skinner, S. Rachel ^{[17
,18
]}

Limson, Genara ^{[19
]}

Szarewski, Anne ^{[20
]}

Romanowski, Barbara ^{[21
]}

Aoki, Fred Y. ^{[22
]}

Schwarz, Tino F. ^{[23
,24
]}

Poppe, Willy A. J. ^{[25
]}

Xavier Bosch, F. ^{[1
,26
]}

de Carvalho, Newton S. ^{[27
]}

Peters, Klaus ^{[28
]}

Tjalma, Wiebren A. A. ^{[29
]}

Safaeian, Mahboobeh ^{[30
]}

Raillard, Alice ^{[31
]}

Descamps, Dominique ^{[32
]}

Struyf, Frank ^{[32
]}

Dubin, Gary ^{[33
]}

Rosillon, Dominique ^{[32
]}

Baril, Laurence ^{[32
]}

机构：

[1] CIBER ESP, IDIBELL, Unit Infect & Canc, Inst Catala Oncol,Canc Epidemiol Res Program, Lhospitalet De Llobregat, Catalonia, Spain

[2] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Gynecol & Obstet, BR-90046900 Porto Alegre, RS, Brazil

[3] Natl Taiwan Univ, Coll Med & Hosp, Dept Obstet & Gynecol, Taipei 10764, Taiwan

[4] Univ New Mexico, Dept Pathol, Hlth Sci Ctr, Albuquerque, NM 87131 USA

[5] Univ New Mexico, Dept Obstet & Gynecol, Hlth Sci Ctr, Albuquerque, NM 87131 USA

[6] Univ Philippines, Dept Obstet & Gynaecol, Coll Med, Philippine Gen Hosp, Manila, Philippines

[7] Univ Tampere, Sch Publ Hlth, FIN-33101 Tampere, Finland

[8] Univ Helsinki, Dept Obstet & Gynaecol, FIN-00014 Helsinki, Finland

[9] Chulalongkorn Univ, Fac Med, Dept Obstet & Gynaecol, Bangkok 10330, Thailand

[10] Univ Melbourne, Royal Womens Hosp, Dept Microbiol & Infect Dis, Parkville, Vic 3052, Australia

[11] Univ Melbourne, Dept Microbiol, Royal Childrens Hosp, Parkville Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[12] Univ Melbourne, Dept Obstet & Gynaecol, Parkville, Vic 3052, Australia

[13] Inst Mexicano Seguro Social, Unidad Invest Epidemiol & Serv Salud, Cuernavaca, Morelos, Mexico

[14] Family Federat Finland, Sexual Hlth Clin, Helsinki, Finland

[15] Cent Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[16] Univ Estadual Campinas, Dept Tocoginecol, UNICAMP, Sao Paulo, Brazil

[17] Telethon Inst Child Hlth Res, Vaccines Trials Grp, Perth, WA, Australia

[18] Univ Sydney, Discipline Paediat & Child Hlth, Childrens Hosp Westmead, Sydney, NSW 2006, Australia

[19] Univ Philippines, Coll Med, Philippine Gen Hosp, Makati Med Ctr, Makati, Philippines

[20] Queen Mary Univ London, Wolfson Inst Prevent Med, Ctr Canc Prevent, London, England

[21] Univ Alberta, Dept Med, Div Infect Dis, Fac Med & Dent, Edmonton, AB, Canada

[22] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[23] Univ Wurzburg, Cent Lab, Stiftung Juliusspital, Acad Teaching Hosp, Wurzburg, Germany

[24] Univ Wurzburg, Vaccinat Ctr, Stiftung Juliusspital, Acad Teaching Hosp, Wurzburg, Germany

[25] KU Leuven Gasthuisberg, Univ Hosp, Dept Gynaecol, Leuven, Belgium

[26] RTICC, Network Cooperat Canc Res, Catalonia, Spain

[27] Univ Fed Parana, Dept Gynecol & Obstet, Infect Dis Gynecol & Obstet Sect, BR-80060000 Curitiba, Parana, Brazil

[28] Facharzt Frauenheilkunde & Geburtshilfe, Hamburg, Germany

[29] Univ Antwerp, Univ Antwerp Hosp, Multidisciplinary Breast Clin Gynecol Oncol, Antwerp, Belgium

[30] NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, Rockville, MD USA

[31] 4Clinics, Paris, France

[32] GlaxoSmithKline Vaccines, Wavre, Belgium

[33] GlaxoSmithKline Vaccines, King Of Prussia, PA USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2014年 / 210卷 / 04期

关键词：

HPV; naturally acquired antibodies; infection; cervical abnormality; risk reduction; HPV-16/18 AS04-ADJUVANTED VACCINE; SUBSEQUENT HPV INFECTION; VIRUS-LIKE PARTICLES; OF-STUDY ANALYSIS; YOUNG-WOMEN; DOUBLE-BLIND; COSTA-RICA; INTRAEPITHELIAL NEOPLASIA; CONTROLLED-TRIAL; EFFICACY;

D O I：

10.1093/infdis/jiu139

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. We examined risk of newly detected human papillomavirus (HPV) infection and cervical abnormalities in relation to HPV type 16/18 antibody levels at enrollment in PATRICIA (Papilloma Trial Against Cancer in Young Adults; NCT00122681). Methods. Using Poisson regression, we compared risk of newly detected infection and cervical abnormalities associated with HPV-16/18 between seronegative vs seropositive women (15-25 years) in the control arm (DNA negative at baseline for the corresponding HPV type [HPV-16: n = 8193; HPV-18: n = 8463]). Results. High titers of naturally acquired HPV-16 antibodies and/or linear trend for increasing antibody levels were significantly associated with lower risk of incident and persistent infection, atypical squamous cells of undetermined significance or greater (ASCUS+), and cervical intraepithelial neoplasia grades 1/2 or greater (CIN1+, CIN2+). For HPV-18, although seropositivity was associated with lower risk of ASCUS+ and CIN1+, no association between naturally acquired antibodies and infection was demonstrated. Naturally acquired HPV-16 antibody levels of 371 (95% confidence interval [CI], 242-794), 204 (95% CI, 129-480), and 480 (95% CI, 250-5756) EU/mL were associated with 90% reduction of incident infection, 6-month persistent infection, and ASCUS+, respectively. Conclusions. Naturally acquired antibodies to HPV-16, and to a lesser extent HPV-18, are associated with some reduced risk of subsequent infection and cervical abnormalities associated with the same HPV type.

引用

页码：517 / 534

页数：18

共 35 条

[1]

af Geijersstam V, 1998, J INFECT DIS, V177, P1710, DOI 10.1086/517428

[2] Prevalence and risk factors for cervical HPV infection and abnormalities in young adult women at enrolment in the multinational PATRICIA trial [J].

Bahmanyar, Edith Roset ;

Paavonen, Jorma ;

Naud, Paulo ;

Salmeron, Jorge ;

Chow, Song-Nan ;

Apter, Dan ;

Kitchener, Henry ;

Castellsague, Xavier ;

Teixeira, Julio C. ;

Skinner, S. Rachel ;

Jaisamrarn, Unnop ;

Limson, Genara A. ;

Garland, Suzanne M. ;

Szarewski, Anne ;

Romanowski, Barbara ;

Aoki, Fred ;

Schwarz, Tino F. ;

Poppe, Willy A. J. ;

De Carvalho, Newton S. ;

Harper, Diane M. ;

Bosch, F. Xavier ;

Raillard, Alice ;

Descamps, Dominique ;

Struyf, Frank ;

Lehtinen, Matti ;

Dubin, Gary .

GYNECOLOGIC ONCOLOGY, 2012, 127 (03) :440-450

[3] The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women [J].

Carter, JJ ;

Koutsky, LA ;

Wipf, GC ;

Christensen, ND ;

Lee, SK ;

Kuypers, J ;

Kiviat, N ;

Galloway, DA .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (05) :927-936

[4] Comparison of human papillomavirus types 16, 18, and 6 capsid antibody responses following incident infection [J].

Carter, JJ ;

Koutsky, LA ;

Hughes, JP ;

Lee, SK ;

Kuypers, J ;

Kiviat, N ;

Galloway, DA .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (06) :1911-1919

[5] Seroprevalence and Correlates of Human Papillomavirus 16/18 Seropositivity Among Young Women in Costa Rica [J].

Coseo, Sarah ;

Porras, Carolina ;

Hildesheim, Allan ;

Cecilia Rodriguez, Ana ;

Schiffman, Mark ;

Herrero, Rolando ;

Wacholder, Sholom ;

Gonzalez, Paula ;

Wang, Sophia S. ;

Sherman, Mark E. ;

Jimenez, Silvia ;

Solomon, Diane ;

Bougelet, Catherine ;

van Doorn, Leen-Jan ;

Quint, Wim ;

Safaeian, Mahboobeh .

SEXUALLY TRANSMITTED DISEASES, 2010, 37 (11) :706-714

[6] Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study [J].

de Sanjose, Silvia ;

Quint, Wim G. V. ;

Alemany, Laia ;

Geraets, Daan T. ;

Ellen Klaustermeier, Jo ;

Lloveras, Belen ;

Tous, Sara ;

Felix, Ana ;

Eduardo Bravo, Luis ;

Shin, Hai-Rim ;

Vallejos, Carlos S. ;

Alonso de Ruiz, Patricia ;

Lima, Marcus Aurelho ;

Guimera, Nuria ;

Clavero, Omar ;

Alejo, Maria ;

Llombart-Bosch, Antonio ;

Cheng-Yang, Chou ;

Alejandro Tatti, Silvio ;

Kasamatsu, Elena ;

Iljazovic, Ermina ;

Odida, Michael ;

Prado, Rodrigo ;

Seoud, Muhieddine ;

Grce, Magdalena ;

Usubutun, Alp ;

Jain, Asha ;

Hernandez Suarez, Gustavo Adolfo ;

Estuardo Lombardi, Luis ;

Banjo, Aekunbiola ;

Menendez, Clara ;

Javier Domingo, Efren ;

Velasco, Julio ;

Nessa, Ashrafun ;

Chichareon, Saibua C. Bunnag ;

Qiao, You Lin ;

Lerma, Enrique ;

Garland, Suzanne M. ;

Sasagawa, Toshiyuki ;

Ferrera, Annabelle ;

Hammouda, Doudja ;

Mariani, Luciano ;

Pelayo, Adela ;

Steiner, Ivo ;

Oliva, Esther ;

Meijer, Chris J. L. M. ;

Al-Jassar, Waleed Fahad ;

Cruz, Eugenia ;

Wright, Thomas C. ;

Puras, Ana .

LANCET ONCOLOGY, 2010, 11 (11) :1048-1056

[7] Correlation between direct ELISA, single epitope-based inhibition ELISA and pseudovirion-based neutralization assay for measuring anti-HPV-16 and anti-HPV-18 antibody response after vaccination with the AS04-adjuvanted HPV-16/18 cervical cancer vaccine [J].

Dessy, Francis J. ;

Giannini, Sandra L. ;

Bougelet, Catherine A. ;

Kemp, Troy J. ;

David, Marie-Pierre M. ;

Poncelet, Sylviane M. ;

Pinto, Ligia A. ;

Wettendroff, Martine A. .

HUMAN VACCINES, 2008, 4 (06) :425-434

[8] Serum antibodies to human papillomavirus (HPV) pseudovirions correlate with natural infection for 13 genital HPV types [J].

Faust, Helena ;

Jelen, Mateja M. ;

Poljak, Mario ;

Klavs, Irena ;

Ucakar, Veronika ;

Dillner, Joakim .

JOURNAL OF CLINICAL VIROLOGY, 2013, 56 (04) :336-341

[9] Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases [J].

Garland, Suzanne M. ;

Hernandez-Avila, Mauricio ;

Wheeler, Cosette M. ;

Perez, Gonzalo ;

Harper, Diane M. ;

Leodolter, Sepp ;

Tang, Grace W. K. ;

Ferris, Daron G. ;

Steben, Marc ;

Bryan, Janine ;

Taddeo, Frank J. ;

Railkar, Radha ;

Esser, Mark T. ;

Sings, Heather L. ;

Nelson, Micki ;

Boslego, John ;

Sattler, Carlos ;

Barr, Eliav ;

Koutsky, Laura A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (19) :1928-1943

[10] Risk factors for subsequent cervicovaginal human papillomavirus (HPV) infection and the protective role of antibodies to HPV-16 virus-like particles [J].

Ho, GYF ;

Studentsov, Y ;

Hall, CB ;

Bierman, R ;

Beardsley, L ;

Lempa, M ;

Burk, RD .

JOURNAL OF INFECTIOUS DISEASES, 2002, 186 (06) :737-742

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