The influence of skeletal muscle on systemic aging and lifespan

被引：181
作者：
Demontis, Fabio [1 ,2 ]
Piccirillo, Rosanna [3 ,4 ]
Goldberg, Alfred L. [3 ]
Perrimon, Norbert [1 ,5 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[2] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Div Dev Biol, Memphis, TN 38105 USA
[3] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
[4] IRCCS, Mario Negri Inst Pharmacol Res, Dept Oncol, Milan, Italy
[5] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
AGING CELL | 2013年 / 12卷 / 06期
关键词：
exercise; intertissue communication during aging; myokine signaling; skeletal muscle aging; systemic aging; MYOSTATIN INHIBITION; GLUCOSE-HOMEOSTASIS; DIETARY RESTRICTION; ALZHEIMERS-DISEASE; ENERGY-METABOLISM; FLIGHT ACTIVITY; EXERCISE; AGE; MICE; LONGEVITY;
D O I：
10.1111/acel.12126
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.
引用
收藏
页码：943 / 949
页数：7
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