Central retinal vein occlusion associated with platelet activation

Purpose: The aim of this article is to determine and compare the platelet activation by three main platelet activation parameters: mean platelet volume, platelet distribution width, and plateletcrit in patients with central retinal vein occlusion and control subjects. Methods: This study included 30 patients with nonischemic central retinal vein occlusion and 30 control subjects. The levels of mean platelet volume, platelet distribution width, and plateletcrit were measured in all groups. Results: The mean serum level of mean platelet volume was 10.01 +/- 0.89 fl in central retinal vein occlusion group and 8.74 +/- 1.45 fl in control group. The mean serum level of platelet distribution width was 14.31 +/- 1.49% and 11.65 +/- 1.81% in central retinal vein occlusion group and control group, respectively. Mean serum plateletcrit value was 0.27 +/- 0.07% in central retinal vein occlusion group and 0.23 +/- 0.07% in control group. Mean platelet volume, platelet distribution width, and plateletcrit levels were significantly higher in central retinal vein occlusion patients than controls (p < 0.05). Conclusion: Subclinical platelet activation reflected by mean platelet volume, platelet distribution width, and plateletcrit may have an impact on the genesis of vessel occlusion in central retinal vein occlusion. The results may be important for the clinical management of patients with central retinal vein occlusion.