Synthesis and Biological Evaluation of 5,6-Dihydro-benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer's Disease Drugs

被引：5

作者：

Zhou, Jinpei ^{[2
]}

Hu, Xiaowen ^{[1
]}

Zhang, Huibin ^{[3
]}

Qian, Hai ^{[3
]}

Huang, Wenlong ^{[3
]}

Qi, Fan ^{[2
]}

Zhang, Yanchun ^{[2
]}

机构：

[1] Nanjing Med Univ, Dept Math & Comp, Nanjing 210029, Peoples R China

[2] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China

[3] China Pharmaceut Univ, Ctr Drug Discovery, Nanjing 210009, Peoples R China

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 08期

关键词：

Alzheimer's disease; Cholinesterase inhibitors; Neuroprotection; INHIBITORS;

D O I：

10.2174/157018009789353527

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The multifactorial pathogenesis of Alzheimer's disease (AD) suggests that drug treatments with two or more mechanisms of action, acting in a complementary manner, could be more efficacious to patients suffering from the disease. In an effort to develop new therapies to treat AD, a series of 5,6-dihydro-benzo[c] acridin-7-ol derivatives (5a-5q) were synthesized and evaluated for their AchE-inhibition and neuron-protection effects. Preliminary biological tests suggested that these compounds exhibited mild AchE-inhibition and commendable neuroprotection activities. Compounds 5m, 5n, 5p had noticeable neuron-protection as compared with tacrine and nimodipine.

引用

页码：623 / 628

页数：6

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