Expression of MACC1, HGF and Met gene in the prognosis of colorectal cancer patients with liver metastasis

Colorectal cancer patients are predisposed for liver metastasis after surgery. Metastasis associated factor 1 of colorectal carcinoma (MACC1), hepatocellular growth factor (HGF) and Met signal pathway are all correlated with occurrence of colorectal carcinoma. This study thus examined expressions of MACC1, HGF and Met expression, to analyze their correlation with metastasis and prognosis. A total of 50 patients diagnosed with liver metastatic colorectal carcinoma in our hospital were recruited. 30 colorectal carcinoma patients without metastasis plus 30 benign tumor patients were employed as control. ELISA was employed to measure serum MACC1, HGF and Met contents, while immunohistochemistry (IHC) staining was employed to detect expression of MACC1, HGF and Met, whose correlation with clinical features was analyzed. Metastatic group had significantly elevated MACC1, HGF and Met expression than un-metastatic group (P<0.05), which had higher levels than benign tumors (P<0.05). MACC1, HGF and Met levels were correlated with differentiation grade, number of primary lesion, size, number of liver metastatic lesions, distal metastasis, radio-/chemo-therapy and survival time (P<0.05). Colorectal cancer patients with liver metastasis had high expression of MACC1, HGF and Met, which are related with differentiation grade, number of primary lesions, size, liver metastatic lesion number, distal metastasis, chemo-/radio-therapy and survival times.