Associations between anthropometric indicators in early life and low-grade inflammation, insulin resistance and lipid profile in adolescence

被引：9

作者：

Oliveira-Santos, J. ^{[1
,5
]}

Santos, R. ^{[1
,2
]}

Moreira, C. ^{[1
]}

Abreu, S. ^{[1
]}

Lopes, L. ^{[1
]}

Agostinis-Sobrinho, C. ^{[1
,3
]}

Stratton, G. ^{[4
]}

Mota, J. ^{[1
]}

机构：

[1] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, Porto, Portugal

[2] Univ Wollongong, Fac Social Sci, Early Start Res Inst, Wollongong, NSW, Australia

[3] Klaipeda Univ, Fac Hlth & Sci, Klaipeda, Lithuania

[4] Swansea Univ, Coll Engn, Res Ctr Appl Sports Technol Exercise & Med, Swansea, W Glam, Wales

[5] Rua Dr Placido Costa 91, P-4200450 Porto, Portugal

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2019年 / 29卷 / 08期

基金：

澳大利亚研究理事会;

关键词：

Early life anthropometry; Cardiometabolic biomarkers; Overweight; Adolescents; C-REACTIVE PROTEIN; EARLY WEIGHT-GAIN; LOW-BIRTH-WEIGHT; RISK-FACTORS; MEDITERRANEAN DIET; CARDIOVASCULAR HEALTH; METABOLIC SYNDROME; CHILDREN; MARKERS; OVERWEIGHT;

D O I：

10.1016/j.numecd.2019.05.052

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: The long-term relations between excessive adiposity in early childhood and unfavourable cardiometabolic profiles in later ages are not yet completely understood. We aimed to assess the associations between birth weight (BW) and BMI from 6 months to 6 years of age, with biomarkers indicative of low-grade inflammation, insulin resistance and lipid profiles in adolescence. Methods and results: Retrospective school-based study with 415 Portuguese adolescents (220 girls), mean age of 14.08 +/- 1.6 years old. Anthropometric data from birth to 6 years old was extracted from individual child health book records. Actual weight and height were measured and BMI calculated. Participants were classified at each time point as normal weight or overweight according to WHO reference values. Biomarkers were obtained from venous blood samples. Linear regressions were used to explore the associations between the biomarkers and early life anthropometric indicators. From 2 years onwards, BMI associated positively with the inflammatory score and HOMA-IR in adolescence. Children who were overweight/obese from 2 to 6 years of age presented significantly higher inflammatory score and HOMA-IR later in adolescence. TC/HDL ratio was also positively associated with BMI from the age of 5 years onwards. The associations between BMI and cardiometabolic outcomes remained positive in adolescence, with overweight adolescents presenting a higher inflammatory score, HOMA-IR and TC/HDL than normal weight adolescents. Conclusion: A high BMI from an early age was consistently associated with worse inflammatory and lipid profiles and insulin resistance in adolescence. No associations were found between BW and the same studied outcomes. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

引用

页码：783 / 792

页数：10

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