Primary Cilia as a Possible Link between Left-Right Asymmetry and Neurodevelopmental Diseases

被引：31

作者：

Trulioff, Andrey ^{[1
,3
]}

Ermakov, Alexander ^{[1
,2
]}

Malashichev, Yegor ^{[1
,2
]}

机构：

[1] St Petersburg State Univ, Fac Biol, Dept Vertebrate Zool, Univ Skaya Nab 7-9, St Petersburg 199034, Russia

[2] Inst Expt Med, Dept Ecol Physiol, Mol Neurobiol Lab, Ul Akad Pavlov 12, St Petersburg 197376, Russia

[3] Inst Expt Med, Dept Immunol, Lab Gen Immunol, Ul Akad Pavlov 12, St Petersburg 197376, Russia

来源：

GENES | 2017年 / 8卷 / 02期

基金：

俄罗斯科学基金会;

关键词：

schizophrenia; centrosome; left-right asymmetry; Disc1; PCM-1; pericentrin; abelson helper integrator 1; hamartin; DCDC2; Dyx1c1; TUBEROUS SCLEROSIS COMPLEX; SCHIZOPHRENIA; DISC1; MAJOR DEPRESSIVE DISORDER; DYSLEXIA CANDIDATE GENES; SITUS-INVERSUS TOTALIS; BIPOLAR DISORDER; DEVELOPMENTAL DYSLEXIA; KARTAGENERS-SYNDROME; NEURONAL MIGRATION; JOUBERT-SYNDROME;

D O I：

10.3390/genes8020048

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Cilia have multiple functions in the development of the entire organism, and participate in the development and functioning of the central nervous system. In the last decade, studies have shown that they are implicated in the development of the visceral left-right asymmetry in different vertebrates. At the same time, some neuropsychiatric disorders, such as schizophrenia, autism, bipolar disorder, and dyslexia, are known to be associated with lateralization failure. In this review, we consider possible links in the mechanisms of determination of visceral asymmetry and brain lateralization, through cilia. We review the functions of seven genes associated with both cilia, and with neurodevelopmental diseases, keeping in mind their possible role in the establishment of the left-right brain asymmetry.

引用

页数：24