Towards a Quantitative Understanding of Protein-Lipid Bilayer Interactions at the Single Molecule Level: Opportunities and Challenges

被引：5

作者：

King, Gavin M. ^{[1
,2
]}

Kosztin, Ioan ^{[1
]}

机构：

[1] Univ Missouri, Dept Phys & Astron, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2021年 / 254卷 / 01期

基金：

美国国家科学基金会;

关键词：

DYNAMICS SIMULATIONS; HYDROPHOBIC PEPTIDES; FORCE SPECTROSCOPY; ENERGY LANDSCAPES; MEMBRANE; STABILITY; INSERTION; ADHESION; BINDING; TRANSLOCATION;

D O I：

10.1007/s00232-020-00151-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-lipid interfaces are among the most fundamental in biology. Yet applying conventional techniques to study the biophysical attributes of these systems is challenging and has left many unknowns. For example, what is the kinetic pathway and energy landscape experienced by a polypeptide chain when in close proximity to a fluid lipid bilayer? Here we review the experimental and theoretical progress we have made in addressing this question from a single molecule perspective. Some remaining impediments are also discussed. [GRAPHICS] .

引用

页码：17 / 28

页数：12

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