Engineering the immune system with particles, step-by-step

被引：5
作者：
De Geest, B. G. [1 ]
机构：
[1] Univ Ghent, Dept Pharmaceut, Ghent, Belgium
来源：
MOLECULAR IMMUNOLOGY | 2018年 / 98卷
关键词：
Vaccine; Nanoparticles; Dendritic cells; Multilayers; SYNTHETIC VACCINES; MICROPARTICLES; FACILE;
D O I：
10.1016/j.molimm.2018.02.015
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Biomaterials-based strategies to engineer the immune system have gathered considerable attention the past decade and have opened new avenues for vaccine delivery and for modulating the immune system to fight cancer. This review highlights some of these strategies that involve well-defined particle-based delivery systems that are constructed in a multistep fashion. Particular attention is devoted to the design of micro and nano particles to deliver antigen and molecular adjuvants to antigen presenting immune cell subsets in lymphatic tissue.
引用
收藏
页码：25 / 27
页数：3
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