Asymmetric synthesis of the (2S,4S,6S)-2,4,6-trimethylnonyl subunit of siphonarienes

被引：0

作者：

Díaz, DD ^{[1
]}

Crisóstomo, FRP ^{[1
]}

Martín, VS ^{[1
]}

机构：

[1] Univ La Laguna, Inst Univ Bioorg Antonio Gonzalez, San Cristobal la Laguna 38206, Tenerife, Spain

来源：

ISRAEL JOURNAL OF CHEMISTRY | 2001年 / 41卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The paper describes an asymmetric approach to the synthesis of the (2S,4S,6S)-2,4,6-trimethylnonyl segment of siphonarienes. The key step used is a newly developed methodology to obtain sec-dialkyl acetylenes based on the intramolecular hydride transfer from a secondary gamma-benzyloxy group with well-defined absolute stereochemistry, ensured by a Sharpless asymmetric epoxidation reaction, to a cation generated by Lewis acid treatment of a tertiary Co-2(CO)(6)-complexed propargylic alcohol.

引用

页码：297 / 302

页数：6

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