Meta-Analysis Assessment of GP210 and SP100 for the Diagnosis of Primary Biliary Cirrhosis

被引：28

作者：

Hu, Shi-Ling ^{[1
]}

Zhao, Feng-Rong ^{[2
]}

Hu, Qin ^{[1
]}

Chen, Wei-Xian ^{[1
]}

机构：

[1] Chongqing Med Univ, Hosp 2, Dept Lab Med, Chongqing, Peoples R China

[2] Youyang Peoples Hosp, Dept Gynecol & Obstet, Chongqing, Peoples R China

来源：

PLOS ONE | 2014年 / 9卷 / 07期

基金：

中国国家自然科学基金;

关键词：

NUCLEAR-PORE COMPLEX; ANTINUCLEAR ANTIBODIES; AUTOANTIBODIES; PROTEINS; GLYCOPROTEIN; PREVALENCE; ENVELOPE; TESTS; POLYPEPTIDE; GUIDELINES;

D O I：

10.1371/journal.pone.0101916

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Purpose: To conduct a systematic review of included studies assessing the association of GP210 and SP100 with the risk of primary biliary cirrhosis (PBC) using meta-analysis. Methods: Five databases, the Cochrane Library, MEDLINE, VIP, CNKI, WANFANG were used to detect the role of GP210 and SP100 in diagnosis of PBC. Approximately 13,000 participants from several countries were included in this analysis. Meta-DiSc statistical software was used for analysis. Results: 25 studies on GP210 and 21 studies on SP100 were included in the meta-analysis. The DOR, sensitivity, specificity of GP210 in diagnosis of PBC were 24.854 (11.957-51.660), 0.272 (0.257-0.288), 0.985 (0.982-0.988), respectively, and they were 9.133 (4.739-17.600), 0.231 (0.213-0.249), 0.977 (0.973-0.981) for SP100. Conclusion: Our meta-analysis indicated both GP210 and SP100 had high specificity but low sensitivity in diagnosis of PBC.

引用

页数：9

共 53 条

[21]

[刘妍 LIU Yan], 2009, [临床检验杂志, Chinese Journal of Clinical Laboratory Science], V27, P256

[22] AUTOANTIBODIES AGAINST NUCLEAR ENVELOPE-ASSOCIATED PROTEINS IN PRIMARY BILIARY-CIRRHOSIS [J].

LOZANO, F ;

PARES, A ;

BORCHE, L ;

PLANA, M ;

GALLART, T ;

RODES, J ;

VIVES, J .

HEPATOLOGY, 1988, 8 (04) :930-938

[23]

Lu JianXi Lu JianXi, 2011, China Tropical Medicine, V11, P1303

[24] Rheumatic disorders and primary biliary cirrhosis: an appraisal of 170 Italian patients [J].

Marasini, B ;

Gagetta, M ;

Rossi, V ;

Ferrari, P .

ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (11) :1046-1049

[25] Value of Autoantibody Analysis in the Differential Diagnosis of Chronic Cholestatic Liver Disease [J].

Milkiewicz, Piotr ;

Buwaneswaran, Hayman ;

Coltescu, Catalina ;

Shums, Zakera ;

Norman, Gary L. ;

Heathcote, E. Jenny .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2009, 7 (12) :1355-1360

[26] Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study [J].

Miyachi, K ;

Hankins, RW ;

Matsushima, H ;

Kikuchi, F ;

Inomata, T ;

Horigome, T ;

Shibata, M ;

Onozuka, Y ;

Ueno, Y ;

Hashimoto, E ;

Hayashi, N ;

Shibuya, A ;

Amaki, S ;

Miyakawa, H .

JOURNAL OF AUTOIMMUNITY, 2003, 20 (03) :247-254

[27] Antimitochondrial Antibodies and Other Antibodies in Primary Billary Cirrhosis: Diagnostic and Prognostic Value [J].

Muratori, Luigi ;

Granito, Alessandro ;

Muratori, Paolo ;

Pappas, Georgios ;

Bianchi, Francesco B. .

CLINICS IN LIVER DISEASE, 2008, 12 (02) :261-+

[28] Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis [J].

Muratori, P ;

Muratori, L ;

Ferrari, R ;

Cassani, F ;

Bianchi, G ;

Lenzi, M ;

Rodrigo, L ;

Linares, A ;

Fuentes, D ;

Bianchi, FB .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2003, 98 (02) :431-437

[29] Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis [J].

Nakamura, M ;

Shimizu-Yoshida, Y ;

Takii, Y ;

Komori, A ;

Yokoyama, T ;

Ueki, T ;

Daikoku, M ;

Yano, K ;

Matsumoto, T ;

Migita, K ;

Yatsuhashi, H ;

Ito, M ;

Masaki, N ;

Adachi, H ;

Watanabe, Y ;

Nakamura, Y ;

Saoshiro, T ;

Sodeyama, T ;

Koga, M ;

Shimoda, S ;

Ishibashi, H .

JOURNAL OF HEPATOLOGY, 2005, 42 (03) :386-392

[30] Anti-gp210 and anti-centromere antibodies are different risk factors for the progression of primary biliary cirrhosis [J].

Nakamura, Minoru ;

Kondo, Hisayoshi ;

Mori, Tsuyoshi ;

Komori, Atsumasa ;

Matsuyama, Mutstuni ;

Ito, Masahiro ;

Takii, Yasushi ;

Koyabu, Makiko ;

Yokoyama, Terufumi ;

Migita, Kiyoshi ;

Daikoku, Manabu ;

Abiru, Seigo ;

Yatsuhashi, Hiroshi ;

Takezaki, Eiichi ;

Masaki, Naohiko ;

Sugi, Kazuhiro ;

Honda, Koichi ;

Adachi, Hiroshi ;

Nishi, Hidehiro ;

Watanabe, Yukio ;

Nakamura, Yoko ;

Shimada, Masaaki ;

Komatsu, Tatsuji ;

Saito, Akira ;

Saoshiro, Takeo ;

Harada, Hideharu ;

Sodeyama, Takeshi ;

Hayashi, Shigeki ;

Masumoto, Akihide ;

Sando, Takehiro ;

Yamamoto, Tetsuo ;

Sakai, Hironori ;

Kobayashi, Masakazu ;

Muro, Toyokichi ;

Koga, Michiaki ;

Shums, Zakera ;

Norman, Gary L. ;

Ishibashi, Hiromi .

HEPATOLOGY, 2007, 45 (01) :118-127

← 1 2 3 4 5 6 →