Meta-Analysis Assessment of GP210 and SP100 for the Diagnosis of Primary Biliary Cirrhosis

被引：28
作者：
Hu, Shi-Ling [1 ]
Zhao, Feng-Rong [2 ]
Hu, Qin [1 ]
Chen, Wei-Xian [1 ]
机构：
[1] Chongqing Med Univ, Hosp 2, Dept Lab Med, Chongqing, Peoples R China
[2] Youyang Peoples Hosp, Dept Gynecol & Obstet, Chongqing, Peoples R China
来源：
PLOS ONE | 2014年 / 9卷 / 07期
基金：
中国国家自然科学基金;
关键词：
NUCLEAR-PORE COMPLEX; ANTINUCLEAR ANTIBODIES; AUTOANTIBODIES; PROTEINS; GLYCOPROTEIN; PREVALENCE; ENVELOPE; TESTS; POLYPEPTIDE; GUIDELINES;
D O I：
10.1371/journal.pone.0101916
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Purpose: To conduct a systematic review of included studies assessing the association of GP210 and SP100 with the risk of primary biliary cirrhosis (PBC) using meta-analysis. Methods: Five databases, the Cochrane Library, MEDLINE, VIP, CNKI, WANFANG were used to detect the role of GP210 and SP100 in diagnosis of PBC. Approximately 13,000 participants from several countries were included in this analysis. Meta-DiSc statistical software was used for analysis. Results: 25 studies on GP210 and 21 studies on SP100 were included in the meta-analysis. The DOR, sensitivity, specificity of GP210 in diagnosis of PBC were 24.854 (11.957-51.660), 0.272 (0.257-0.288), 0.985 (0.982-0.988), respectively, and they were 9.133 (4.739-17.600), 0.231 (0.213-0.249), 0.977 (0.973-0.981) for SP100. Conclusion: Our meta-analysis indicated both GP210 and SP100 had high specificity but low sensitivity in diagnosis of PBC.
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页数：9
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