A facile stereoselective synthesis of 2-perfluoroalkyl-3a,4,5, 6-tetrahydroimidazo[1,5-b]isoxazoles

被引：20

作者：

Lu, Lei ^{[1
]}

Cao, Weiguo ^{[1
,2
,3
]}

Chen, Jie ^{[1
]}

Zhang, Hui ^{[1
]}

Zhang, Jiaping ^{[1
]}

Chen, Huiyun ^{[1
]}

Wei, Jiamei ^{[1
]}

Deng, Hongmei ^{[4
]}

Shao, Min ^{[4
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[4] Shanghai Univ, Instrumental Anal & Res Ctr, Shanghai 200444, Peoples R China

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2009年 / 130卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Methyl; 2-perfluoroalkynoates; Imidazoisoxazoles; 1,3-Dipolar cycloaddition; Diastereoselectivity; Regioselectivity; 1,3-DIPOLAR CYCLOADDITION REACTIONS; HETEROCYCLIC-COMPOUNDS; CYCLIC NITRONES; ISOXAZOLIDINES; ALKYNES; ROUTE; BOND;

D O I：

10.1016/j.jfluchem.2008.11.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Methyl 2-perfluoroalkynoates 2 reacted readily with cyclic nitrones 1 via 1,3-dipolar cycloaddition at room temperature to give 2-perfluoroalkyl-3a,4,5,6-tetrahydroimidazo[1,5-b]isoxazoles 3 in good to excellent yields with high diastereoselectivity and regioselectivity. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：295 / 300

页数：6

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