Palladium-catalyzed methylene C(sp3)-H arylation of the adamantyl scaffold

被引：18
作者：
Lao, Ye-Xing [1 ,2 ]
Wu, Jia-Qiang [1 ]
Chen, Yunyun [1 ]
Zhang, Shang-Shi [1 ]
Li, Qingjiang [1 ]
Wang, Honggen [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou 510230, Guangdong, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2015年 / 2卷 / 10期
基金：
中国国家自然科学基金;
关键词：
C-H BONDS; ALPHA-AMINO-ACIDS; UNACTIVATED C(SP(3))-H; ACTIVATION; FUNCTIONALIZATION; HYDROXYLATION; DERIVATIVES; INHIBITOR; DIVERSIFICATION; CONSTRUCTION;
D O I：
10.1039/c5qo00218d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The adamantyl group is prevalent as a key pharmacophore element in drugs. We describe herein a palladium-catalyzed C-H functionalization logic for the methylene C(sp(3))-H arylation of the adamantyl scaffold with the assistance of an amide group. The resulting arylated adamantyl amide was smoothly converted to an amine, providing facile access to the memantine analog.
引用
收藏
页码：1374 / 1378
页数：5
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