Objective: The study was conducted to assess the ergonomic exposures to risk factors that may lead to the reported musculoskeletal injuries (especially back, neck and wrist injuries) of drywall workers. Methods: A hierarchical taxonomy for construction of drywall panel hanging (drywall panel fitting and installation) was developed with activities defined within the interior wall systems tasks (drywall panel, studs and insulation). Exposures were characterized for the drywall panel work with the PATH (Posture, Activity, Tools, and Handling) work-sampling observation method. Data on working postures were collected for three main body parts: legs, arms and trunk. Activities performed for each task, tools used, and manually handled loads were also recorded for each observation. Results: The study identified several ergonomic exposures in interior systems construction. Several risk factors were especially prevalent in the drywall panel installation task: awkward body postures such as overhead arm posture, trunk flexion, and handling of heavy drywall panels. Some tasks were observed to have combinations of these musculoskeletal risk factors, such as drywall panel installation, where the workers lifted heavy drywall panels in awkward body postures. In addition, a safety hazard frequently resulted when a worker's foot was poorly supported on a ladder while lifting heavy drywall panels to hang them on the ceiling or upper wall. Conclusion: The drywall panel installation task poses a severe threat to the safety and musculoskeletal health of the drywall workers. Much of this could be eliminated by reducing the burden of handling heavy and bulky drywall panels. Relevance to industry: The construction industry is well-documented to have high rates of injury and musculoskeletal disorders. Design of appropriate interventions requires specific knowledge of which tasks and activities involve the highest levels of exposure to relevant factors. Assessment of such factors in drywall panel hanging has provided data that will be useful to evaluate the ergonomics efficacy of future changes in task processes or tools. Feasible solutions appear to exist; effectiveness trials and worker input are needed in order to evaluate whether they could eliminate the observed exposures. (C) 2013 Elsevier B.V. All rights reserved.