Design and Structure-Function Characterization of 3D Printed Synthetic Porous Biomaterials for Tissue Engineering

被引：123

作者：

Kelly, Cambre N. ^{[1
]}

Miller, Andrew T. ^{[1
]}

Hollister, Scott J. ^{[2
]}

Guldberg, Robert E. ^{[3
]}

Gall, Ken ^{[1
]}

机构：

[1] Duke Univ, Dept Mech Engn & Mat Sci, Box 90300 Hudson Hall, Durham, NC 27708 USA

[2] Georgia Inst Technol, Coulter Dept Biomed Engn, 313 Ferst Dr,Room 2127, Atlanta, GA 30332 USA

[3] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, 315 Ferst Dr, Atlanta, GA 30332 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2018年 / 7卷 / 07期

关键词：

3D printing; printed architecture; scaffolds; structure-function; tissue engineering;

D O I：

10.1002/adhm.201701095

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

3D printing is now adopted for use in a variety of industries and functions. In biomedical engineering, 3D printing has prevailed over more traditional manufacturing methods in tissue engineering due to its high degree of control over both macro- and microarchitecture of porous tissue scaffolds. However, with the improved flexibility in design come new challenges in characterizing the structure-function relationships between various architectures and both mechanical and biological properties in an assortment of clinical applications. Presently, the field of tissue engineering lacks a comprehensive body of literature that is capable of drawing meaningful relationships between the designed structure and resulting function of 3D printed porous biomaterial scaffolds. This work first discusses the role of design on 3D printed porous scaffold function and then reviews characterization of these structure-function relationships for 3D printed synthetic metallic, polymeric, and ceramic biomaterials.

引用

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