Solid-phase organic chemistry:: Synthesis of 2β-(heterocyclylthiomethyl)penam derivatives on solid support

被引：4

作者：

Delpiccolo, CML ^{[1
]}

Mata, EG ^{[1
]}

机构：

[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis, RA-2000 Rosario, Santa Fe, Argentina

来源：

MOLECULES | 2000年 / 5卷 / 03期

关键词：

D O I：

10.3390/50300537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 2 beta-(heterocyclylthiomethyl)penam derivatives on solid support has been developed. Compounds are obtained in good to high yields (based on loading of the original resin). The key step is the solid-phase double rearrangement of the corresponding penicillin sulfoxide.

引用

页码：537 / 538

页数：2

共 4 条

[1]

BUNIN BA, 1998, COMBINATORIAL INDEX

[2]

DEWITT SH, 1997, PRACTICAL COMBINATOR

[3] Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant Staphylococcus aureus [J].

Hecker, SJ ;

Cho, IS ;

Glinka, TW ;

Zhang, ZJ ;

Price, ME ;

Lee, VJ ;

Christensen, BG ;

Boggs, A ;

Chamberland, S ;

Malouin, F ;

Parr, TR ;

Annamalai, T ;

Blais, J ;

Bond, EL ;

Case, L ;

Chan, C ;

Crase, J ;

Frith, R ;

Griffith, D ;

Harford, L ;

Liu, N ;

Ludwikow, M ;

Mathias, K ;

Rea, D ;

Williams, R .

JOURNAL OF ANTIBIOTICS, 1998, 51 (08) :722-734

[4] beta-lactams on solid support: Mild and efficient removal of penicillin derivatives from Merrifield resin using aluminum chloride [J].

Mata, EG .

TETRAHEDRON LETTERS, 1997, 38 (36) :6335-6338

← 1 →