Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response

被引：71

作者：

von Locquenghien, Michelle ^{[1
]}

Rozalen, Catalina ^{[1
]}

Celia-Terrassa, Toni ^{[1
]}

机构：

[1] IMIM Hosp Mar Med Res Inst, Canc Res Program, Barcelona, Spain

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2021年 / 131卷 / 01期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; TOLL-LIKE RECEPTORS; IFN-GAMMA; TUMOR-CELLS; DOWN-REGULATION; IMMUNE CHECKPOINTS; BONE METASTASIS; STEM-CELLS; E-CADHERIN; T-CELLS;

D O I：

10.1172/JCI143296

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interferons (IFNs) are pleiotropic cytokines critical for regulation of epithelial cell functions and for immune system regulation. In cancer, IFNs contribute to tumor-intrinsic and-extrinsic mechanisms that determine the quality of antitumor immunity and response to immunotherapy. In this Review, we focus on the different types of tumor IFN sensitivity that determine dynamic tumor-immune interactions and their coevolution during cancer progression and metastasis. We extend the discussion to new evidence supporting immunotherapy-mediated immunoediting and the dual opposing roles of IFNs that lead to immune checkpoint blockade response or resistance. Understanding the intricate dynamic responses to IFN will lead to novel immunotherapeutic strategies to circumvent protumorigenic effects of IFN while exploiting IFNmediated antitumor immunity.

引用

页数：13

共 50 条

[41] Biomarkers for immunotherapy response in head and neck cancer [J].

Gavrielatou, Niki ;

Doumas, Stergios ;

Economopoulou, Panagiota ;

Foukas, Periklis G. ;

Psyrri, Amanda .

CANCER TREATMENT REVIEWS, 2020, 84

[42] A microRNA code for prostate cancer metastasis [J].

Bonci, D. ;

Coppola, V. ;

Patrizii, M. ;

Addario, A. ;

Cannistraci, A. ;

Francescangeli, F. ;

Pecci, R. ;

Muto, G. ;

Collura, D. ;

Bedini, R. ;

Zeuner, A. ;

Valtieri, M. ;

Sentinelli, S. ;

Benassi, M. S. ;

Gallucci, M. ;

Carlini, P. ;

Piccolo, S. ;

De Maria, R. .

ONCOGENE, 2016, 35 (09) :1180-1192

[43] Molecular determinants of prostate cancer metastasis [J].

Rycaj, Kiera ;

Tang, Dean G. .

ONCOTARGET, 2017, 8 (50) :88211-88231

[44] Intratumoral heterogeneity in cancer progression and response to immunotherapy [J].

Vitale, Ilio ;

Shema, Efrat ;

Loi, Sherene ;

Galluzzi, Lorenzo .

NATURE MEDICINE, 2021, 27 (02) :212-224

[45] Cancer Immunotherapy and the Immune Response in Hodgkin Lymphoma [J].

Renner, Christoph ;

Stenner, Frank .

FRONTIERS IN ONCOLOGY, 2018, 8

[46] Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion [J].

Schreiber, Robert D. ;

Old, Lloyd J. ;

Smyth, Mark J. .

SCIENCE, 2011, 331 (6024) :1565-1570

[47] Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma [J].

Lorenzo-Sanz, Laura ;

Lopez-Cerda, Marta ;

da Silva-Diz, Victoria ;

Artes, Marta H. ;

Llop, Sandra ;

Penin, Rosa M. ;

Bermejo, Josep Oriol ;

Gonzalez-Suarez, Eva ;

Esteller, Manel ;

Vinals, Francesc ;

Espinosa, Enrique ;

Oliva, Marc ;

Piulats, Josep M. ;

Martin-Liberal, Juan ;

Munoz, Purificacion .

NATURE COMMUNICATIONS, 2024, 15 (01)

[48] Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response [J].

Cheng, Xiangdong ;

Dai, Enyu ;

Wu, Jibo ;

Flores, Natasha M. ;

Chu, Yanshuo ;

Wang, Ruiping ;

Dang, Minghao ;

Xu, Zhiyuan ;

Han, Guangchun ;

Liu, Yunhe ;

Chatterjee, Deyali ;

Hu, Can ;

Ying, Jieer ;

Du, Yian ;

Yang, Litao ;

Guan, Xiaoqing ;

Mo, Shaowei ;

Cao, Xuanye ;

Pei, Guangsheng ;

Jiang, Jiahui ;

Lu, Xiaoyin ;

Benitez, Ana Morales ;

Waters, Rebecca E. ;

Pizzi, Melissa Pool ;

Shanbhag, Namita ;

Fan, Yibo ;

Peng, Fuduan ;

Hanash, Samir M. ;

Calin, George ;

Futreal, Andrew ;

Song, Shumei ;

Yee, Cassian ;

Mazur, Pawel K. ;

Qin, Jiang-Jiang ;

Ajani, Jaffer A. ;

Wang, Linghua .

GASTROENTEROLOGY, 2024, 167 (07) :1345-1357

[49] IL-18 is produced by prostate cancer cells and secreted in response to interferons [J].

Lebel-Binay, S ;

Thiounn, N ;

De Pinieux, G ;

Vieillefond, A ;

Debré, B ;

Bonnefoy, JY ;

Fridman, WH ;

Pagès, F .

INTERNATIONAL JOURNAL OF CANCER, 2003, 106 (06) :827-835

[50] Immunosurveillance and Immunoediting of Lung Cancer: Current Perspectives and Challenges [J].

Kunimasa, Kei ;

Goto, Taichiro .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (02)

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