The effect of astaxanthin on the aging ratbrain: gender-related differences inmodulating inflammation

被引：37

作者：

Balietti, Marta ^{[1
,2
]}

Giannubilo, Stefano R. ^{[3
]}

Giorgetti, Belinda ^{[1
]}

Solazzi, Moreno ^{[1
]}

Turi, Angelo ^{[3
]}

Casoli, Tiziana ^{[1
]}

Ciavattini, Andrea ^{[3
]}

Fattorettia, Patrizia ^{[2
]}

机构：

[1] INRCA Ancona, Neurobiol Aging Ctr, Ancona, Italy

[2] INRCA Ancona, Cellular Bioenerget Lab, Ancona, Italy

[3] Salesi Hosp, Dept Clin Sci, Unit Obstet & Gynecol, Ancona, Italy

来源：

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 2016年 / 96卷 / 02期

关键词：

astaxanthin; brain; aging; inflammation; gender; SEX-HORMONES; BRAIN; MECHANISMS; DAMAGE;

D O I：

10.1002/jsfa.7131

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

BACKGROUNDAstaxanthin (Ax) is a ketocarotenoid of the xanthophyll family with activities such as antioxidation, preservation of the integrity of cell membranes and protection of the redox state and functional integrity of mitochondria. The aim of this study was to investigate potential gender-related differences in the effect of Ax on the aging rat brain. RESULTSIn females, interleukin 1 beta (IL1) was significantly lower in treated rats in both cerebral areas, and in the cerebellum, treated animals also had significantly higher IL10. In males, no differences were found in the cerebellum, but in the hippocampus, IL1 and IL10 were significantly higher in treated rats. CONCLUSIONThese are the first results to show gender-related differences in the effect of Ax on the aging brain, emphasizing the necessity to carefully analyze female and male peculiarities when the anti-aging potentialities of this ketocarotenoid are evaluated. The observations lead to the hypothesis that Ax exerts different anti-inflammatory effects in female and male brains. (c) 2015 Society of Chemical Industry

引用

页码：615 / 618

页数：4

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