Effects of Mesenchymal Stem Cell-Derived Paracrine Signals and Their Delivery Strategies

被引：148
作者：
Chang, Calvin [1 ,2 ,3 ]
Yan, Jerry [1 ,2 ,3 ]
Yao, Zhicheng [2 ,3 ,4 ]
Zhang, Chi [2 ,3 ,4 ]
Li, Xiaowei [5 ,6 ]
Mao, Hai-Quan [1 ,2 ,3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA
[2] Johns Hopkins Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA
[4] Johns Hopkins Univ, Dept Mat Sci & Engn, Whiting Sch Engn, Baltimore, MD 21218 USA
[5] Univ Nebraska Med Ctr, Mary & Dick Holland Regenerat Med Program, Omaha, NE 68198 USA
[6] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE 68198 USA
来源：
ADVANCED HEALTHCARE MATERIALS | 2021年 / 10卷 / 07期
关键词：
biomaterials; extracellular vesicles; mesenchymal stem cells; microRNA; paracrine signaling; secretome; STROMAL CELLS; EXTRACELLULAR VESICLES; BONE-MARROW; THERAPY; TISSUE; ENGRAFTMENT; INJURY; MACROPHAGES; SPHEROIDS; EXOSOMES;
D O I：
10.1002/adhm.202001689
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials-based therapeutic strategies for delivery of MSCs and MSC-derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
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页数：17
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