Effects of Mesenchymal Stem Cell-Derived Paracrine Signals and Their Delivery Strategies

被引：135
作者：
Chang, Calvin [1 ,2 ,3 ]
Yan, Jerry [1 ,2 ,3 ]
Yao, Zhicheng [2 ,3 ,4 ]
Zhang, Chi [2 ,3 ,4 ]
Li, Xiaowei [5 ,6 ]
Mao, Hai-Quan [1 ,2 ,3 ,4 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Biomed Engn, Baltimore, MD 21205 USA
[2] Johns Hopkins Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA
[4] Johns Hopkins Univ, Dept Mat Sci & Engn, Whiting Sch Engn, Baltimore, MD 21218 USA
[5] Univ Nebraska Med Ctr, Mary & Dick Holland Regenerat Med Program, Omaha, NE 68198 USA
[6] Univ Nebraska Med Ctr, Dept Neurol Sci, Omaha, NE 68198 USA
来源：
ADVANCED HEALTHCARE MATERIALS | 2021年 / 10卷 / 07期
关键词：
biomaterials; extracellular vesicles; mesenchymal stem cells; microRNA; paracrine signaling; secretome; STROMAL CELLS; EXTRACELLULAR VESICLES; BONE-MARROW; THERAPY; TISSUE; ENGRAFTMENT; INJURY; MACROPHAGES; SPHEROIDS; EXOSOMES;
D O I：
10.1002/adhm.202001689
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Mesenchymal stem cells (MSCs) have been widely studied as a versatile cell source for tissue regeneration and remodeling due to their potent bioactivity, which includes modulation of inflammation response, macrophage polarization toward proregenerative lineage, promotion of angiogenesis, and reduction in fibrosis. This review focuses on profiling the effects of paracrine signals of MSCs, commonly referred to as the secretome, and highlighting the various engineering approaches to tune the MSC secretome. Recent advances in biomaterials-based therapeutic strategies for delivery of MSCs and MSC-derived secretome in the form of extracellular vesicles are discussed, along with their advantages and challenges.
引用
收藏
页数：17
相关论文
共 136 条
  • [1] Abdeen AA, 2014, TISSUE ENG PT A, V20, P2737, DOI [10.1089/ten.tea.2013.0661, 10.1089/ten.TEA.2013.0661]
  • [2] Effective Prevention of Liver Fibrosis by Liver-targeted Hydrodynamic Gene Delivery of Matrix Metalloproteinase-13 in a Rat Liver Fibrosis Model
    Abe, Hiroyuki
    Kamimura, Kenya
    Kobayashi, Yuji
    Ohtsuka, Masato
    Miura, Hiromi
    Ohashi, Riuko
    Yokoo, Takeshi
    Kanefuji, Tsutomu
    Suda, Takeshi
    Tsuchida, Masanori
    Aoyagi, Yutaka
    Zhang, Guisheng
    Liu, Dexi
    Terai, Shuji
    [J]. MOLECULAR THERAPY-NUCLEIC ACIDS, 2016, 5 : e276
  • [3] The effects of hypoxia on the stemness properties of human dental pulp stem cells (DPSCs)
    Ahmed, Nermeen El-Moataz Bellah
    Murakami, Masashi
    Kaneko, Satoru
    Nakashima, Misako
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [4] Engraftment Patterns of Human Adult Mesenchymal Stem Cells Expose Electrotonic and Paracrine Proarrhythmic Mechanisms in Myocardial Cell Cultures
    Askar, Said F. A.
    Ramkisoensing, Arti A.
    Atsma, Douwe E.
    Schalij, Martin J.
    de Vries, Antoine A. F.
    Pijnappels, Daniel A.
    [J]. CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, 2013, 6 (02) : 380 - 391
  • [5] Exploring a Role for Regulatory miRNAs In Wound Healing during Ageing: Involvement of miR-200c in wound repair
    Aunin, Eerik
    Broadley, David
    Ahmed, Mohammed I.
    Mardaryev, Andrei N.
    Botchkareva, Natalia V.
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [6] MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death
    Aurora, Arin B.
    Mahmoud, Ahmed I.
    Luo, Xiang
    Johnson, Brett A.
    van Rooij, Eva
    Matsuzaki, Satoshi
    Humphries, Kenneth M.
    Hill, Joseph A.
    Bassel-Duby, Rhonda
    Sadek, Hesham A.
    Olson, Eric N.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (04) : 1222 - 1232
  • [7] Aggregation of human mesenchymal stromal cells (MSCs) into 3D spheroids enhances their antiinflammatory properties
    Bartosh, Thomas J.
    Ylostalo, Joni H.
    Mohammadipoor, Arezoo
    Bazhanov, Nikolay
    Coble, Katie
    Claypool, Kent
    Lee, Ryang Hwa
    Choi, Hosoon
    Prockop, Darwin J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (31) : 13724 - 13729
  • [8] CDC25A targeting by miR-483-3p decreases CCND-CDK4/6 assembly and contributes to cell cycle arrest
    Bertero, T.
    Gastaldi, C.
    Bourget-Ponzio, I.
    Mari, B.
    Meneguzzi, G.
    Barbry, P.
    Ponzio, G.
    Rezzonico, R.
    [J]. CELL DEATH AND DIFFERENTIATION, 2013, 20 (06) : 800 - 811
  • [9] Brown KJ, 2012, EXPERT REV PROTEOMIC, V9, P337, DOI [10.1586/epr.12.21, 10.1586/EPR.12.21]
  • [10] Mass spectrometric analysis of the in vitro secretome from equine bone marrow-derived mesenchymal stromal cells to assess the effect of chondrogenic differentiation on response to interleukin-1β treatment
    Bundgaard, Louise
    Stensballe, Allan
    Elbaek, Kirstine Juul
    Berg, Lise Charlotte
    [J]. STEM CELL RESEARCH & THERAPY, 2020, 11 (01)
12345678910