Histone deacetylase inhibitors regulate p21WAF1 gene expression at the post-transcriptional level in HepG2 cells

被引：34

作者：

Hirsch, CL

Bonham, K

机构：

[1] Univ Saskatchewan, Saskatchewan Canc Agcy, Hlth Res Div, Canc Res Unit, Saskatoon, SK S7N 4H4, Canada

[2] Univ Saskatchewan, Coll Med, Div Oncol, Saskatoon, SK S7N 4H4, Canada

[3] Univ Saskatchewan, Dept Biochem, Saskatoon, SK S7N 5E5, Canada

来源：

FEBS LETTERS | 2004年 / 570卷 / 1-3期

基金：

加拿大健康研究院;

关键词：

mRNA stability; histone deacetylase inhibitor; p2l(WAF1);

D O I：

10.1016/j.febslet.2004.06.018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Histone deacetylase inhibitors (HDIs) are thought to act primarily at the level of transcription inducing cell cycle arrest, differentiation and/or apoptosis in many cancer cell types. Induction of the potent cdk/cyclin inhibitor p21(WAF1) is a key feature of this HDI mediated transcriptional re-programming phenomenon. However, in the current study we report that HDIs are also capable of inducing p21(WAF1) through purely posttranscriptional events, namely increased mRNA stability. These studies highlight our growing appreciation for the complexities of HDI mediated effects and challenge our preconceptions regarding the action of these promising anti-neoplastics. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：37 / 40

页数：4

共 19 条

[1] p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells [J].