Induction of gene encoding FABP4 in Pten-null keratinocytes

被引：17

作者：

Tsuda, Masaaki ^{[1
]}

Inoue-Narita, Tae ^{[1
]}

Suzuki, Akira ^{[2
]}

Itami, Satoshi ^{[3
]}

Blumenberg, Miroslav ^{[4
]}

Manabe, Motomu ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Dermatol & Plast Surg, Akita 0108543, Japan

[2] Kyushu Univ, Med Inst Bioregulat, Div Embryon & Genet Engn, Fukuoka 812, Japan

[3] Osaka Univ, Grad Sch Med, Dept Regenerat Dermatol, Osaka, Japan

[4] NYU, Sch Med, Dept Dermatol, New York, NY USA

来源：

FEBS LETTERS | 2009年 / 583卷 / 08期

关键词：

Pten; FABP4; PPAR gamma; Sebaceous gland; Microarray; ACID-BINDING PROTEIN; EPIDERMAL-KERATINOCYTES; SEBACEOUS GLAND; BETA-CATENIN; SKIN; DIFFERENTIATION; EXPRESSION; ROLES; GAMMA; CELL;

D O I：

10.1016/j.febslet.2009.03.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten-null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte-specific fatty acid-binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1319 / 1322

页数：4

共 24 条

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