Synthesis of Substituted Acridines through a Palladium-Catalyzed Condensation/Cyclization/Tautomerization Sequence

被引：21

作者：

Chen, Xiangui ^{[1
]}

YanjunXie ^{[1
]}

Li, Cheng ^{[1
]}

Xiao, Fuhong ^{[1
]}

Deng, Guo-Jun ^{[1
,2
,3
]}

机构：

[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China

[2] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[3] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Cyclization; Dehydrogenation; Nitrogen heterocycles; Palladium; Tautomerism; LIGHT-EMITTING-DIODES; METAL-FREE CONDITIONS; ONE-POT SYNTHESIS; FACILE SYNTHESIS; DEHYDROGENATIVE AROMATIZATION; AEROBIC DEHYDROGENATION; UNSYMMETRICAL ACRIDINES; O-ACYLANILINES; HOST MATERIAL; C-H;

D O I：

10.1002/ejoc.201601553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report an efficient strategy for the synthesis of 9-aryl-substituted acridines from cyclohexanones and 2-aminobenzophenones in the presence of a palladium catalyst. Molecular oxygen is applied as a green oxidant. Various cyclo-hexanones acted as the aryl source to construct the nitrogen-containing heterocycles through a condensation/cyclization/tautomerization sequence.

引用

页码：577 / 581

页数：5

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