Microwave-Assisted Synthesis of 4-Substituted 2-Methylthiopyrimidines

被引：5

作者：

Thomann, Andreas ^{[1
]}

Boerger, Carsten ^{[2
]}

Empting, Martin ^{[1
]}

Hartmann, Rolf W. ^{[1
,3
]}

机构：

[1] Univ Saarland, Helmholtz Inst Pharmaceut Res Saarland, D-66123 Saarbrucken, Germany

[2] Univ Saarland, PharmBioTec GmbH, D-66123 Saarbrucken, Germany

[3] Univ Saarland, D-66123 Saarbrucken, Germany

来源：

SYNLETT | 2014年 / 25卷 / 07期

关键词：

green chemistry; pyrimidine; combinatorial chemistry; medicinal chemistry; nucleophilic aromatic substitution; BIOLOGICAL EVALUATION; DERIVATIVES; ROUTES;

D O I：

10.1055/s-0033-1340860

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Typically, SNAr reactions at 4-chloro-2-methylthiopyrimidine are carried out employing DMF and sodium hydride under inert gas as well as prolonged reaction times. Herein, we describe a mild and rapid microwave-assisted synthesis to achieve 4-substituted 2-methylthiopyrimidnes from the corresponding chlorine precursor. Moderate to excellent yields were obtained in a green chemistry fashion requiring only few minutes of reaction time.

引用

页码：935 / 938

页数：4

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