Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals

被引：35

作者：

Park, Young Kyoung ^{[1
]}

Cho, Ji Young ^{[1
]}

Jung, Sook-In ^{[3
]}

Park, Kyong-Hwa ^{[3
]}

Lee, Hyuck ^{[4
]}

Jung, Dong Sik ^{[4
]}

Heo, Sang Taek ^{[5
]}

Kim, Shin-Woo ^{[6
]}

Chang, Hyun-Ha ^{[6
]}

Cheong, Hae Suk ^{[7
]}

Chung, Doo Ryeon ^{[7
]}

Peck, Kyong Ran ^{[7
]}

Song, Jae-Hoon ^{[2
,7
]}

Ko, Kwan Soo ^{[1
,2
]}

机构：

[1] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 440746, South Korea

[2] Asian Pacific Res Fdn Infect Dis, Seoul 135710, South Korea

[3] Chonnam Natl Univ, Sch Med, Div Infect Dis, Kwangju 501757, South Korea

[4] Dong A Univ Hosp, Div Infect Dis, Pusan 602715, South Korea

[5] Gyeongsang Natl Univ, Sch Med, Gyeongsang Inst Hlth Sci, Dept Internal Med, Jinju 660702, South Korea

[6] Kyungpook Natl Univ Hosp, Sch Med, Div Infect Dis, Taegu 700721, South Korea

[7] Sungkyunkwan Univ, Samsung Med Ctr, Div Infect Dis, Sch Med, Seoul 135710, South Korea

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 64卷 / 04期

关键词：

Acinetobacter baumannii; Imipenem; Meropenem; Colistin; Multilocus sequence typing (MLST); Carbapenemase; FIELD GEL-ELECTROPHORESIS; BETA-LACTAMASE; HIGH PREVALENCE; GENE; IDENTIFICATION; INFECTIONS; CHALLENGE; PATTERNS; IMPACT; SPREAD;

D O I：

10.1016/j.diagmicrobio.2009.03.029

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We investigated the characteristics of 48 carbapenem-resistant Acinetobacter baumannii isolates collected from 5 tertiary care hospitals in Korea by multilocus sequencing typing, pulsed-field gel electrophoresis, and polymerase chain reaction amplification of the antimicrobial resistance determinants. We identified 2 distinct main clones of carbapenem-resistant A. baumannii isolates, which showed different antimicrobial resistance profiles and are also differentiated by the kinds of oxacillinase (OXA) carbapenemases and Acinetobacter-derived cephalosporinase (ADC) beta-lactamases. One main clone, ST22:A, had 27 carbapenem-resistant isolates (56.3%), showed high polymyxin B and colistin resistances (33.3% and 37.0%, respectively), and contained both bla(OXA-51-like) and bla(OXA-23-like) genes and the bla(ADC-29) or bla(ADC-30) gene. In contrast, the other main clone, ST28:B, included 15 isolates (31.3%), showed complete susceptibilities to polymyxin B and colistin. and contained only the bla(OXA-51-like) gene and bla(ADC-31) or bla(ADC-32) genes. The distribution of these main carbapenem-resistant A. baumannii clones did not relate to locality, indicating that they are widespread in Korean hospitals. In addition, we found new types of PER beta-lactamases, PER-6. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：389 / 395

页数：7

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