Regulation of cell function by Rho family GTPases

被引：80
作者：
Bokoch, GM
机构：
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USA
来源：
IMMUNOLOGIC RESEARCH | 2000年 / 21卷 / 2-3期
关键词：
Rho GTPases; kinases; neutrophils; actin cytoskeleton; signal transduction; cell death; oxidants;
D O I：
10.1385/IR:21:2-3:139
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Rho GTPases act as molecular switches to control many basic cellular activities that are also critical to the specialized functions of phagocytic leukocytes. Our laboratory has studied the regulation of Rho GTPase function, how these GTPases interact with specific effecters to modulate cell function, and how these events are coordinated in the stimulated cell. Areas of major interest include NADPH oxidase regulation by Rac2, Rac- and Cdc42-mediated control of the actin-myosin cytoskeleton via p21-activated kinase (PAK), and modulation of the apoptotic program by Rho GTPases and PAK.
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收藏
页码：139 / 148
页数：10
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