Hyalinizing trabecular adenoma of the thyroid gland - Identification through MIB-1 staining of fine-needle aspiration biopsy smears

被引：47
作者：
Casey, MB [1 ]
Sebo, TJ [1 ]
Carney, JA [1 ]
机构：
[1] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
来源：
AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2004年 / 122卷 / 04期
关键词：
fine-needle aspiration biopsy; hyalinizing trabecular adenoma; medullary thyroid carcinoma; MIB-1; immunostaining; papillary thyroid carcinoma;
D O I：
10.1309/KLJU9LVBLLA6CL76
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Smears offine-needle aspiration (FNA) biopsy specimens of 24 histologically proven and MIB-1-positive hyalinizing trabecular adenomas stained with Papanicolaou or Diff-Quik were stripped from the original slides, transferred to charged slides, destained, and restained with MIB-1. Positive immunoreactivity with MIB-1 in a peripheral cytoplasmic pattern was present in 17 specimens, no immunoreactivity was seen in 4 specimens, and equivocal staining was seen in 3 specimens. Papanicolaou-stained smears of papillary thyroid carcinoma, medullary thyroid carcinoma, thyroid follicular neoplasm, and Hurthle cell adenoma (5 specimens each) were treated similarly. None of the control cases stained with MIB- I had the peripheral cytoplasmic pattern. Hyalinizing trabecular adenoma can be distinguished reliably from other thyroid neoplasms by MIB-1 staining of destained cells from FNA biopsy specimens.
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收藏
页码：506 / 510
页数：5
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