A two-photon benzocoumarin-NBD dyad for highly selective and sensitive ratiometric detection of H2S in biological samples

被引：11

作者：

Gao, Jingshuo ^{[1
]}

Jia, Xu ^{[1
]}

Guo, Zhenbo ^{[1
]}

Yang, Shuhan ^{[1
]}

Wei, Lingyu ^{[1
]}

Zhang, Pingzhu ^{[1
]}

Wei, Chao ^{[1
]}

Chen, Guofeng ^{[1
]}

Li, Xiaoliu ^{[1
]}

机构：

[1] Hebei Univ, Coll Chem & Environm Sci, Key Lab Med Chem & Mol Diag, Key Lab Chem Biol Hebei Prov,Minist Educ, Baoding 071002, Peoples R China

来源：

DYES AND PIGMENTS | 2021年 / 185卷 / 185期

关键词：

H2S; Dual-photon; Ratiometric; Benzocoumarin-NBD; Bioimaging; HYDROGEN-SULFIDE; FLUORESCENT-PROBE; LIVING CELLS;

D O I：

10.1016/j.dyepig.2020.108906

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Hydrogen sulfide (H2S), the third endogenous gas signaling transmitter, plays an important role in the basic signal conduction process of human physiology and pathology. It is critical to monitor the dynamic change of H2S in living organisms. In this article, a two-photon ratiometric fluorescent probe (BCD) based on the benzocoumarin-NBD framework was first designed and synthesized. The probe showed large emission separation (about 115 nm), excellent selectivity, and high sensitivity. Moreover, it could be applied to ratiometric image endogenous H2S biosynthesis in the living cells and zebrafish.

引用

页数：6

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