Synthetic approaches to benzimidazoles from O-phenylenediamine: A literature review

被引：159

作者：

Alaqeel, Shatha Ibrahim ^{[1
]}

机构：

[1] Coll Sci, Dept Chem, King Saud Univ 034, Riyadh 11495, Saudi Arabia

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2017年 / 21卷 / 02期

关键词：

Benzimidazole nucleus; o-Phenylenediamine; Pharmacological activity; Therapeutic compound; DERIVATIVES; AGENTS;

D O I：

10.1016/j.jscs.2016.08.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The methods for the synthesis of benzimidazoles have become a focus of synthetic organic chemists, as they are useful building blocks for the development of important therapeutic compounds in medicine. Benzimidazole nucleus plays a very important role as a therapeutic agent e.g. antiulcer and anthelmintic drugs. Other benzimidazole derivatives exhibit pharmacological activities such as antimicrobial, antiviral, anticancer, anti-inflammatory and analgesic. (C) 2016 King Saud University.

引用

页码：229 / 237

页数：9

共 32 条

[1] Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[μ2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(μ2-CH2CH2NHNCC6H4)PdCl]2•C2H5OH complex [J].

Aghatabay, Naz M. ;

Somer, M. ;

Senel, M. ;

Dulger, B. ;

Gucin, F. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (08) :1069-1075

[2] A parallel-group comparison of astemizole and loratadine for the treatment of perennial allergic rhinitis [J].

AlMuhaimeed, H .

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 1997, 25 (04) :175-181

[3]

Aniket P., 2015, Int. J. ChemTech Res., V8, P496

[4]

Austel V., 1989, [No title captured], Patent No. 19870825

[5]

Austel V., 1989, [No title captured], Patent No. 3728244

[6]

Austel V., 1989, [No title captured], Patent No. 873728244

[7]

Birajdar S.S., 2014, Res. J. Pharm., Biol. Chem. Sci., V5, P487

[8] CHEMISTRY OF VITAMIN B12 GROUP [J].

BONNETT, R .

CHEMICAL REVIEWS, 1963, 63 (06) :573-&

[9] Novel structure's derived from 2-[[(2-Pyridyl)methyl]thio]-1H-benzimidazole as anti-Helicobacter pylori agents, part 2 [J].

Carcangue, D ;

Shue, YK ;

Wuonola, MA ;

Uria-Nickelsen, M ;

Joubran, C ;

Abedi, JK ;

Jones, J ;

Kühler, TC .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (19) :4300-4309

[10] Synthesis and analgesic activities of some 2-(benzazolylacetyl)amino-3-ethoxycarbonylthiophene derivatives [J].

Demirayak, S ;

Karaburun, AC ;

Kayagil, I ;

Uçucu, U ;

Beis, R .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (08) :1841-1848

← 1 2 3 4 →