Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites

被引：146

作者：

Healer, J

Crawford, S

Ralph, S

McFadden, G

Cowman, AF

机构：

[1] Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia

[2] Univ Melbourne, Sch Bot, Melbourne, Vic, Australia

来源：

INFECTION AND IMMUNITY | 2002年 / 70卷 / 10期

关键词：

D O I：

10.1128/IAI.70.10.5751-5758.2002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) contains an N-terminal propeptide that is removed prior to the translocation of the mature protein onto the merozoite surface. We localized unprocessed PfAMA1 to the microneme organelles of the intraerythrocytic schizont. The results have suggested that the processed form of PfAMA1 translocates from the microneme compartment independently of another microneme protein, EBA175, which is also involved in the invasion of human erythrocytes.

引用

收藏

页码：5751 / 5758

页数：8

相关论文

共 44 条

[1] ERYTHROCYTE ENTRY BY MALARIAL PARASITES - MOVING JUNCTION BETWEEN ERYTHROCYTE AND PARASITE [J].

AIKAWA, M ;

MILLER, LH ;

JOHNSON, J ;

RABBEGE, J .

JOURNAL OF CELL BIOLOGY, 1978, 77 (01) :72-82

[2] FINE STRUCTURE OF ERYTHROCYTIC STAGES OF 3 AVIAN MALARIAL PARASITES PLASMODIUM FALLAX P LOPHURAE AND P CATHEMERIUM [J].

AIKAWA, M .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1966, 15 (04) :449-&

[3] Malaria vaccines [J].

Anders, RF ;

Saul, A .

PARASITOLOGY TODAY, 2000, 16 (10) :444-447

[4] Immunisation with recombinant AMA-1 protects mice against infection with Plasmodium chabaudi [J].

Anders, RF ;

Crewther, PE ;

Edwards, S ;

Margetts, M ;

Matthew, MLSM ;

Pollock, B ;

Pye, D .

VACCINE, 1998, 16 (2-3) :240-247

[5]

Baldini A, 2000, ZEI STUD EU ECON LAW, V2, P19

[6] STRUCTURE AND INVASIVE BEHAVIOR OF PLASMODIUM-KNOWLESI MEROZOITES INVITRO [J].

BANNISTER, LH ;

BUTCHER, GA ;

DENNIS, ED ;

MITCHELL, GH .

PARASITOLOGY, 1975, 71 (DEC) :483-&

[7]

BARNWELL J, 1998, INVASION VERTEBRATE

[8] A REPETITIVE ANTIGEN OF PLASMODIUM-FALCIPARUM THAT IS HOMOLOGOUS TO HEAT-SHOCK PROTEIN 70 OF DROSOPHILA-MELANOGASTER [J].

BIANCO, AE ;

FAVALORO, JM ;

BURKOT, TR ;

CULVENOR, JG ;

CREWTHER, PE ;

BROWN, GV ;

ANDERS, RF ;

COPPEL, RL ;

KEMP, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (22) :8713-8717

[9] Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii [J].

Brydges, SD ;

Sherman, GD ;

Nockemann, S ;

Loyens, A ;

Däubener, W ;

Dubremetz, JF ;

Carruthers, VB .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2000, 111 (01) :51-66

[10] The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases [J].

Carruthers, VB ;

Sherman, GD ;

Sibley, LD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (19) :14346-14353

← 1 2 3 4 5 →