Photochemical Properties of Octaphenyl-Substituted Erbium Phthalocyanine

被引：4

作者：

Burtsev, I. D. ^{[1
]}

Egorov, A. E. ^{[1
]}

Kostyukov, A. A. ^{[1
]}

Shibaeva, A., V ^{[1
]}

Klimovich, M. A. ^{[1
]}

Kosov, A. D. ^{[2
]}

Seliverstov, M. Yu ^{[2
]}

Dubinina, T., V ^{[2
]}

Markova, A. A. ^{[1
,3
]}

Kuzmin, V. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Emanuel Inst Biochem Phys, Moscow, Russia

[2] Moscow MV Lomonosov State Univ, Fac Chem, Moscow, Russia

[3] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, Moscow, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY B | 2022年 / 16卷 / 01期

关键词：

phthalocyanines; photochemistry; triplet states; fluorescence; photodynamic therapy; localization in cells; confocal spectroscopy; PHOTOLUMINESCENCE QUANTUM YIELD; LUMINESCENCE PROPERTIES; PHOTODYNAMIC THERAPY; COMPLEXES; PHOTOSENSITIZERS; CELLS;

D O I：

10.1134/S1990793122010195

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The spectral-kinetic characteristics of the singlet and triplet excited states of octaphenyl-substituted erbium phthalocyanine are established. It is shown that the compound has high values of the quantum yields of fluorescence (0.50) and singlet oxygen (0.43). The lifetimes of the excited singlet (4.9 ns) and triplet states (1.4 ms) are determined. The binding constant of phthalocyanine to bovine serum albumin (5.5 x 10(6) M-1) is calculated, indicating the effective binding of the test substance to albumin. The predominant accumulation of the dye in the cell cytoplasm on the model colon adenocarcinoma cell line (HCT116 cell line) is established. The localization of phthalocyanine in mitochondria and structures of the endoplasmic reticulum is established by confocal microscopy.

引用

页码：109 / 117

页数：9

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