Interleukin-18:: biological properties and clinical implications

被引：1
|
作者：
Lebel-Binay, S
Berger, A
Zinzindohoué, F
Cugnenc, PH
Thiounn, N
Fridman, WH
Pagès, F
机构：
[1] Univ Paris 06, Lab Univ Transfert Immunol, Paris, France
[2] Inst Curie, INSERM, U255, Paris, France
[3] Hop Laennec, Serv Chirurg Gen Digest & Oncol, F-75340 Paris, France
[4] Hop Cochin, Serv Urol, F-75674 Paris, France
来源：
EUROPEAN CYTOKINE NETWORK | 2000年 / 11卷 / 01期
关键词：
IL-18; IFN-gamma; Th1; differentiation; inflammation; clinical implications;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.
引用
收藏
页码：15 / 25
页数：11
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