Interleukin-18:: biological properties and clinical implications

被引：1

作者：

Lebel-Binay, S

Berger, A

Zinzindohoué, F

Cugnenc, PH

Thiounn, N

Fridman, WH

Pagès, F

机构：

[1] Univ Paris 06, Lab Univ Transfert Immunol, Paris, France

[2] Inst Curie, INSERM, U255, Paris, France

[3] Hop Laennec, Serv Chirurg Gen Digest & Oncol, F-75340 Paris, France

[4] Hop Cochin, Serv Urol, F-75674 Paris, France

来源：

EUROPEAN CYTOKINE NETWORK | 2000年 / 11卷 / 01期

关键词：

IL-18; IFN-gamma; Th1; differentiation; inflammation; clinical implications;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases.

引用

页码：15 / 25

页数：11

共 50 条

[31] Interleukin-18: Biology and Role in the Immunotherapy of Cancer
Srivastava, S.
Salim, N.
Robertson, M. J.
CURRENT MEDICINAL CHEMISTRY, 2010, 17 (29) : 3353 - 3357
[32] Interleukin-18 regulates pathological intraocular neovascularization
Qiao, Hong
Sonoda, Koh-Hei
Ikeda, Yasuhiro
Yoshimura, Takeru
Hijioka, Kuniaki
Jo, Young-Joon
Sassa, Yukio
Tsutsumi-Miyahara, Chikako
Hata, Yasuaki
Akira, Shizuo
Ishibashi, Tatsuro
JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (04) : 1012 - 1021
[33] Role of Interleukin-18 in the Development and Pathogenesis of AIDS
Iannello, Alexandre
Samarani, Suzanne
Debbeche, Olfa
Tremblay, Cecile
Toma, Emil
Boulassel, Mohamed-Rachid
Routy, Jean-Pierre
Ahmad, Ali
AIDS REVIEWS, 2009, 11 (03) : 115 - 125
[34] Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients
Ojala, Johanna
Alafuzoff, Irina
Herukka, Sanna-Kaisa
van Groen, Thomas
Tanila, Heikki
Pirttila, Tuula
NEUROBIOLOGY OF AGING, 2009, 30 (02) : 198 - 209
[35] Interleukin-18 Binding Protein in the Sera of Patients with Wegener's Granulomatosis
Novick, D.
Elbirt, D.
Dinarello, C. A.
Rubinstein, M.
Sthoeger, Z. M.
JOURNAL OF CLINICAL IMMUNOLOGY, 2009, 29 (01) : 38 - 45
[36] High circulating levels of free interleukin-18 in patients with active SLE in the presence of elevated levels of interleukin-18 binding protein
Novick, Daniela
Elbirt, Daniel
Miller, Galit
Dinarello, Charles A.
Rubinstein, Menachem
Sthoeger, Zev M.
JOURNAL OF AUTOIMMUNITY, 2010, 34 (02) : 121 - 126
[37] Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Kim, Eun Gyul
Leem, Ji Su
Baek, Seung Min
Kim, Hye Rin
Kim, Kyung Won
Kim, Mi Na
Sohn, Myung Hyun
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2022, 14 (04) : 424 - 438
[38] Clinical significance of interleukin-18 and interleukin-10 in patients with chronic obstructive pulmonary disease combined with hypertension
Melenevych, A. Ya.
ZAPOROZHYE MEDICAL JOURNAL, 2018, (05) : 623 - 627
[39] Interleukin-18 mediates interleukin-1-induced cardiac dysfunction
Toldo, Stefano
Mezzaroma, Eleonora
O'Brien, Laura
Marchetti, Carlo
Seropian, Ignacio M.
Voelkel, Norbert F.
Van Tassell, Benjamin W.
Dinarello, Charles A.
Abbate, Antonio
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2014, 306 (07): : H1025 - H1031
[40] Interleukin-18 is a crucial determinant of vulnerability of the mouse rectum to psychosocial stress
Nishida, Kensei
Kamizato, Mai
Kawai, Tomoko
Masuda, Kiyoshi
Takeo, Keiko
Teshima-Kondo, Shigetada
Tanahashi, Toshihito
Rokutan, Kazuhito
FASEB JOURNAL, 2009, 23 (06) : 1797 - 1805

← 1 2 3 4 5 →