Isoliquiritigenin inhibits the proliferation and induces the apoptosis of human non-small cell lung cancer A549 cells

被引：79

作者：

Hsu, YL

Kuo, PL

Chiang, LC

Lin, CC

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 807, Taiwan

[3] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan, Taiwan

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 2004年 / 31卷 / 07期

关键词：

A549; apoptosis; Fas; Fas ligand; isoliquiritigenin; p53;

D O I：

10.1111/j.1440-1681.2004.04016.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Isoliquiritigenin (ISL) is a natural pigment with the simple chalcone structure 4,2',4'-trihydroxychalcone. In the present study, we report, for the first time, ISL-induced inhibition of the proliferation of the human non-small cell lung cancer A549 cell line. 2. The results showed that ISL not only inhibited A549 cell proliferation, but also induced apoptosis and blocked cell cycle progression in the G1 phase. An ELISA assay demonstrated that ISL significantly increased the expression of p53 and p21/WAF1 protein, which caused cell cycle arrest. 3. An enhancement in Fas and its two ligands, namely membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), may be responsible for the apoptotic effect induced by ISL. 4. Taken together, the results indicate that the p53 and Fas/FasL apoptotic system may participate in the antiproliferative activity of ISL in A549 cells.

引用

页码：414 / 418

页数：5

共 22 条

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