Theranostics dye integrated zwitterionic polymer for in vitro and in vivo photothermal cancer therapy

被引：26

作者：

Kang, Eun Bi ^{[1
]}

Lee, Jung Eun ^{[2
]}

Jeong, Ji Hoon ^{[2
]}

Lee, Gibaek ^{[1
]}

In, Insik ^{[3
,4
]}

Park, Sung Young ^{[1
,4
]}

机构：

[1] Korea Natl Univ Transportat, Dept Chem & Biol Engn, Chungju 380702, South Korea

[2] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, Gyeonggi Do, South Korea

[3] Korea Natl Univ Transportat, Dept Polymer Sci & Engn, Chungju 380702, South Korea

[4] Korea Natl Univ Transportat, Dept IT Convergence, Chungju 380702, South Korea

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2016年 / 33卷

基金：

新加坡国家研究基金会;

关键词：

Bioimaging; BODIPY; IR825; Zwitterionic; Photothermal therapy; REDUCED GRAPHENE OXIDE; CARBON NANOPARTICLES; DRUG-DELIVERY; ORGANIC-DYE; BODIPY; SYSTEMS;

D O I：

10.1016/j.jiec.2015.10.026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report that combining diagnostic bioimaging fluorescence and photothermal therapeutic (PTT) within a single nano-platform can be used to simultaneously and accurately diagnose and ablate tumors. The integrated pH with thermo-responsive poly(dimethylaminoethyl methacrylate-co-N-isopropylacylamide) sulfobetaine (PDNS) backbone carrier retained optical bioimaging from boron dipyrromethane (BODIPY) and sufficient photothermal generation is ensured by integrating IR825 within this same theranostic system. BODIPY (fluorescence dye) with IR825 (NIR dye) quaternized zwitterionic PDNS (IR825/BOD-PDNS) showed pH and temperature-dependent fluorescence emissions and NIR irradiated in vitro photothermal toxicity to cancer cells. This fluorescence platform maximizes the antitumor response, monitors treatment condition, and successfully ablates tumors with thermal energy. (C) 2015 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：336 / 344

页数：9

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