Concise synthesis of aromatic tertiary amines via a double Petasis-borono Mannich reaction of aromatic amines, formaldehyde, and organoboronic acids

被引：18
作者：
Wang, Jiayi [1 ]
Li, Pinzhen [1 ]
Shen, Qiaoying [1 ]
Song, Gonghua [1 ]
机构：
[1] E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 29期
关键词：
Petasis-borono Mannich reaction; Organoboronic acids; Aromatic amines; Formaldehyde; Multi-component reaction; CATALYZED ELECTROPHILIC AMINATION; BORROWING HYDROGEN METHODOLOGY; MULTICOMPONENT REACTIONS; REDUCTIVE AMINATION; ARYLBORONIC ACIDS; N-ALKYLATION; NUCLEOPHILIC-SUBSTITUTION; DIORGANOZINC REAGENTS; COUPLING REACTIONS; CUPRIC ACETATE;
D O I：
10.1016/j.tetlet.2014.03.131
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient strategy to construct aromatic tertiary amines via a double Petasis-borono Mannich reaction of aromatic amines, formaldehyde, and organoboronic acids has been developed. The transformation provides a useful method for the synthesis of amine derivatives. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3888 / 3891
页数：4
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