Fabrication and evaluation of ascorbic acid phosphate-loaded spherical porous hydroxyapatite/octacalcium phosphate granules

被引：5

作者：

Kamitakahara, Masanobu ^{[1
]}

Ishii, Airi ^{[1
]}

Matsubara, Hideaki ^{[1
]}

Kawashita, Masakazu ^{[2
]}

Furuya, Maiko ^{[3
]}

Kanetaka, Hiroyasu ^{[3
]}

机构：

[1] Tohoku Univ, Grad Sch Environm Studies, Aoba Ku, 6-6-20 Aoba, Sendai, Miyagi 9808579, Japan

[2] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan

[3] Tohoku Univ, Grad Sch Dent, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan

来源：

JOURNAL OF THE CERAMIC SOCIETY OF JAPAN | 2021年 / 129卷 / 01期

关键词：

Octacalcium phosphate; Hydroxyapatite; Core/shell structure; Artificial bone; Ascorbic acid; OCTACALCIUM PHOSPHATE; BONE-FORMATION; HYDROLYSIS; REPAIR;

D O I：

10.2109/jcersj2.20170

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The spherical porous granules of octacalcium phosphate (OCP) and hydroxyapatite (HA) have the potential for applications in scaffolds for bone regeneration. The spherical porous alpha-tricalcium phosphate granules were immersed in a pH 5.0 buffer solution that contained 0.1 mM of ascorbic acid phosphate (AscP), an osteogenesispromoting drug, at 60 degrees C. This resulted in the fabrication of the AscP-loaded spherical porous HA/OCP granules. The OCP and HA phases were concentrated at the surface and interior of the granules, respectively. Furthermore, the HA/OCP core/shell-like structure of the granules was observed for the first time. The loaded AscP in the HA/OCP granules was slowly released in a pH 7.4 buffer solution. The differentiation of the osteoblast-like cells was promoted by the AscP-loaded HA/OCP granules. These granules possessed the potential for applications in artificial bones to promote bone regeneration. (C) 2021 The Ceramic Society of Japan. All rights reserved.

引用

页码：60 / 65

页数：6

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