Short synthesis of the 6,6-spiroketal cores of spirofungins A and B

被引：37

作者：

Dias, LC ^{[1
]}

de Oliveira, LG ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Quim, BR-13084971 Campinas, SP, Brazil

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 15期

关键词：

D O I：

10.1021/ol0491078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9-C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach uses a very efficient alkylation of a lithiated N,N-dimethylhydrazone followed by spiroketal formation under acidic conditions.

引用

页码：2587 / 2590

页数：4

共 19 条

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