Long-term anabolic steroids in male bodybuilders induce cardiovascular structural and autonomic abnormalities

被引：29

作者：

Barbosa Neto, Octavio ^{[1
,5
]}

da Mota, Gustavo Ribeiro ^{[1
]}

De Sordi, Carla Cristina ^{[2
]}

Resende, Elisabete Aparecida M. R. ^{[2
]}

Resende, Luiz Antonio P. R. ^{[3
]}

Vieira da Silva, Marco Antonio ^{[3
]}

Marocolo, Moacir ^{[4
]}

Cortes, Rafael Silva ^{[5
]}

de Oliveira, Lucas Felipe ^{[5
]}

Dias da Silva, Valdo Jose ^{[5
]}

机构：

[1] Univ Fed Triangulo Mineiro, Human Performance & Sport Res Grp, Postgrad Program Phys Educ, Ave Tutunas 490, BR-38061500 Uberaba, MG, Brazil

[2] Univ Fed Triangulo Mineiro, Sch Med, Dept Endocrinol & Metab, Uberaba, MG, Brazil

[3] Univ Fed Triangulo Mineiro, Sch Med, Dept Cardiol, Uberaba, MG, Brazil

[4] Univ Fed Juiz de Fora, Dept Physiol, Juiz De Fora, MG, Brazil

[5] Univ Fed Triangulo Mineiro, Inst Biol & Nat Sci, Dept Physiol, Uberaba, MG, Brazil

来源：

CLINICAL AUTONOMIC RESEARCH | 2018年 / 28卷 / 02期

关键词：

Anabolic androgenic steroids; Autonomic nervous system; Heart rate variability; Nonlinear symbolic dynamics; HEART-RATE-VARIABILITY; LEFT-VENTRICULAR HYPERTROPHY; CARDIAC SYMPATHETIC TONE; LOW-FREQUENCY POWER; ANDROGENIC STEROIDS; SYMBOLIC DYNAMICS; BLOOD-PRESSURE; BODY-BUILDERS; QT DISPERSION; SUDDEN-DEATH;

D O I：

10.1007/s10286-017-0470-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aims of this study were to examine the hypothesis that users of anabolic androgenic steroids (AAS) would have cardiac autonomic disorders and that there is a correlation between sympathetic modulation, high blood pressure (BP) and alterations to cardiac dimensions. Forty-five male subjects were enrolled in the study. They were categorized into three groups comprising bodybuilders actively using AAS (AAS users; n = 15), bodybuilders who had never used AAS (nonusers; n = 15) and age-paired healthy sedentary controls (n = 15). Hemodynamic parameters, linear and nonlinear analyses of heart rate variability and electrocardiography and echocardiography analyses were performed at rest. Bodybuilders in the AAS group had a higher mean BP than those in the ASS nonuser group (p < 0.05) and the sedentary controls (p < 0.001). Cardiac sympathetic modulation was higher in AAS users than in AAS nonusers (p < 0.05) and the sedentary controls (p < 0.001), and parasympathetic modulation was lower in AAS users than in nonusers and the sedentary controls (p < 0.05). Shannon entropy was lower in AAS users than in the sedentary (p < 0.05) controls, and the corrected QT interval and QT dispersion were higher in AAS users than in the sedentary controls (p < 0.05). The interventricular septal thickness, left ventricle posterior wall thickness and relative diastolic wall thickness were higher in AAS users than in AAS nonusers and the sedentary controls (p < 0.001). AAS users showed a positive correlation between increased sympathetic modulation and high BP (r = 0.48, p < 0.005), as well as sympathetic modulation and cardiac hypertrophy (r = 0.66, p < 0.001). There was a marked cardiac autonomic alteration in AAS users, with a shift toward sympathetic modulation predominance and vagal attenuation. The high BP observed in our group of bodybuilders using AAS was associated with increased sympathetic modulation, and this increased sympathetic modulation was associated with structural alterations in the heart. This association may constitute an important mechanism linking AAS abuse to increased cardiovascular risk.

引用

页码：231 / 244

页数：14

共 72 条

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