Investigation of TLR5 and TLR7 as candidate genes for susceptibility to systemic lupus erythematosus

被引：0

作者：

Sanchez, E. ^{[1
]}

Callejas-Rubio, J. L. ^{[2
]}

Sabio, J. M. ^{[3
]}

Gonzalez-Gay, M. A. ^{[4
]}

Jimenez-Alonso, J. ^{[3
]}

Mico, L. ^{[5
]}

de Ramon, E. ^{[6
]}

Camps, M. ^{[6
]}

Suarez, A. ^{[7
]}

Gutierrez, C. ^{[7
]}

Garcia-Portales, R. ^{[8
]}

Tolosa, C. ^{[9
]}

Ortego-Centeno, N. ^{[2
]}

Sanchez-Roman, J. ^{[10
]}

Garcia-Hernandez, F. J. ^{[10
]}

Gonzalez-Escribano, M. F. ^{[11
]}

Martin, J. ^{[1
]}

Lopez-Nevot, M. A. ^{[12
]}

机构：

[1] CSIC, Inst Parasitol & Biomed Lopez Neyra, Granada 18100, Spain

[2] Hosp Clin San Cecilio, Med Interna Serv, Granada, Spain

[3] Hosp Virgen Nieves, Med Interna Serv, Granada, Spain

[4] Hosp Xeral Calde, Serv Reumatol, Lugo, Spain

[5] Hosp La Fe, Med Interna Serv, E-46009 Valencia, Spain

[6] Hosp Carlos Haya, Med Interna Serv, Malaga, Spain

[7] Univ Oviedo, Hosp Cent Asturias, Dept Biol Func, Oviedo, Spain

[8] Hosp Virgen Victoria, Med Interna Serv, Malaga, Spain

[9] Hosp Parc Tauli, Med Interna Serv, Sabadell, Spain

[10] Hosp Virgen Rocio, Med Interna Serv, Seville, Spain

[11] Hosp Virgen Rocio, Serv Inmunol, Seville, Spain

[12] Hosp Virgen Nieves, Serv Inmunol, Granada, Spain

来源：

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2009年 / 27卷 / 02期

关键词：

Polymorphisms; systemic lupus erythematosus; susceptibility; toll-like receptors; TOLL-LIKE RECEPTORS; STOP CODON POLYMORPHISM; INNATE IMMUNE-RESPONSE; HUMAN-DISEASE; ASSOCIATION; FLAGELLIN; TOLL-LIKE-RECEPTOR-5; AUTOIMMUNITY; INDUCTION;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective The aim of this study was to evaluate the relevance of genetic variants of TLR5 (rs5744168) and TLR7 (rs179008) gene in systemic lupus erythematosus (SLE) in a Spanish population. Material and methods Our study population consisted of 752 SLE patients and 1107 healthy controls. All individual were of Spanish Caucasian origin. The TLR5 and TLR7 polymorphisms were genotyped using a PCR system with pre-developed TaqMan allelic discrimination assay. Results No statistically significant differences were observed when the allele and genotype distribution of TLR5 rs5744168 and TLR7 rs179008 polymorphisms wets compared between SLE patients and healthy controls. A significant increase frequency in the CC genotype of the TLR5 rs5744168 polymorphism among SLE patients without nephritis was found (93% vs. 87% in SLE patients with nephritis, p=0.03, OR=2.11 95%CI 0.93-3.51). However, this difference did not reach statistical significance in the allele frequencies (p=0.08). Conclusion These results suggest that the tested variations of TLR5 and TLR7 genes do not confer a relevant role in the susceptibility or severity to SLE in the Spanish population.

引用

页码：267 / 271

页数：5

共 38 条

[11] A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease [J].

Hawn, TR ;

Verbon, A ;

Lettinga, KD ;

Zhao, LP ;

Li, SS ;

Laws, RJ ;

Skerrett, SJ ;

Beutler, B ;

Schroeder, L ;

Nachman, A ;

Ozinsky, A ;

Smith, KD ;

Aderem, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (10) :1563-1572

[12] The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 [J].

Hayashi, F ;

Smith, KD ;

Ozinsky, A ;

Hawn, TR ;

Yi, EC ;

Goodlett, DR ;

Eng, JK ;

Akira, S ;

Underhill, DM ;

Aderem, A .

NATURE, 2001, 410 (6832) :1099-1103

[13] Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [J].

Hochberg, MC .

ARTHRITIS AND RHEUMATISM, 1997, 40 (09) :1725-1725

[14] Toll-like receptor control of the adaptive immune responses [J].

Iwasaki, A ;

Medzhitov, R .

NATURE IMMUNOLOGY, 2004, 5 (10) :987-995

[15] Unresponsiveness of MyD88-deficient mice to endotoxin [J].

Kawai, T ;

Adachi, O ;

Ogawa, T ;

Takeda, K ;

Akira, S .

IMMUNITY, 1999, 11 (01) :115-122

[16] Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects [J].

Kelley, James ;

Johnson, Martin R. ;

Alarcon, Graciela S. ;

Kimberly, Robert P. ;

Edberg, Jeffrey C. .

ARTHRITIS AND RHEUMATISM, 2007, 56 (10) :3375-3378

[17] Coordinate overexpression of interferon-α-induced genes in systemic lupus erythematosus [J].

Kirou, KA ;

Lee, C ;

George, S ;

Louca, K ;

Papagiannis, LG ;

Peterson, MGE ;

Ly, N ;

Woodward, RN ;

Fry, KE ;

Lau, AYH ;

Prentice, JG ;

Wohlgemuth, JG ;

Crow, MK .

ARTHRITIS AND RHEUMATISM, 2004, 50 (12) :3958-3967

[18] Toll-like receptors and innate immune responses in systemic lupus erythematosus [J].

Lafyatis, Robert ;

Marshak-Rothstein, Ann .

ARTHRITIS RESEARCH & THERAPY, 2007, 9 (06)

[19] Tolling for Autoimmunity - Prime time for 7 [J].

Marshak-Rothstein, Ann .

IMMUNITY, 2006, 25 (03) :397-399

[20] Genome scan of human systemic lupus erythematosus:: Evidence for linkage on chromosome 1q in African-American pedigrees [J].

Moser, KL ;

Neas, BR ;

Salmon, JE ;

Yu, H ;

Gray-McGuire, C ;

Asundi, N ;

Bruner, GR ;

Fox, J ;

Kelly, J ;

Henshall, S ;

Bacino, D ;

Dietz, M ;

Hogue, R ;

Koelsch, G ;

Nightingale, L ;

Shaver, T ;

Abdou, NI ;

Albert, DA ;

Carson, C ;

Petri, M ;

Treadwell, EL ;

James, JA ;

Harley, JB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) :14869-14874

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