PEG-linked luminescent platinum(II) complex as aqueous polymeric molecular light switch for protein binding reactions

被引：65
作者：
Che, CM
Zhang, JL
Lin, LR
机构：
[1] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Inst Mol Technol Drug Discovery & Synth, Open Lab Chem Biol, Hong Kong, Hong Kong, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2002年 / 21期
关键词：
D O I：
10.1039/b207395a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Attachment of poly(ethylene glycol) (PEG) to [Pt(4-HOPh-C<^>N<^>N)Cl] via covalent etheric bonds yields the luminescent polymer PEG-[Pt] (2), the photoluminescence of which is enhanced in hydrophobic regions of protein molecules (binding constant up to 10(4) M-1) in aqueous solution; complex 2 can function as a luminescent probe for protein denaturation due to urea unfolding reaction.
引用
收藏
页码：2556 / 2557
页数：2
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