Engraftment of human blood malignancies to the turkey embryo: A robust new in vivo model

被引：11

作者：

Grinberg, Igor ^{[1
]}

Reis, Arbel ^{[1
]}

Ohana, Avivit ^{[1
]}

Taizi, Moran ^{[1
]}

Cipok, Michal ^{[3
]}

Tavor, Sigal ^{[3
,4
]}

Rund, Deborah ^{[2
]}

Deutsch, Varda R. ^{[3
]}

Goldstein, Ronald S. ^{[1
]}

机构：

[1] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel

[2] Hebrew Univ Jerusalem, Hadassah Hosp, Dept Hematol, Jerusalem, Israel

[3] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Inst Hematol, IL-69978 Tel Aviv, Israel

[4] Tel Aviv Univ, Fac Med, IL-69978 Tel Aviv, Israel

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 10期

关键词：

Xenografts; Chick embryo; Chemotherapy testing; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; NOD/SCID MICE; CHICK-EMBRYO; HUMAN-CELLS; QUANTIFICATION; GROWTH; EFFICACY; THERAPY; RELAPSE;

D O I：

10.1016/j.leukres.2009.02.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Xenografting of human blood malignancies to immunodeficient SCID mice is a powerful research tool. We evaluate here whether the immunodeficient turkey embryo can also serve as a xenograft host for human blood malignancies. Human leukemia, lymphoma and myeloma lines engrafted robustly into medullary and extramedullary tissues of turkey embryos as detected by PCR, FACS and histology in 8-10 days. Four of eleven patient AML samples also engrafted the bone marrow. Grafts of two lines responded to chemotherapy with doxorubicin. The turkey embryo therefore has the potential to be a complementary xenograft model for the study of human blood malignancies. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1417 / 1426

页数：10

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