Modulation of presynaptic calcium transients by metabotropic glutamate receptor activation: A differential role in acute depression of synaptic transmission and long-term depression

被引：2
作者：
Faas, GC [1 ]
Adwanikar, H [1 ]
Gereau, RW [1 ]
Saggau, P [1 ]
机构：
[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
来源：
JOURNAL OF NEUROSCIENCE | 2002年 / 22卷 / 16期
关键词：
mGluR; DHPG; LTD; presynaptic; calcium; hippocampus;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Activation of group I metabotropic glutamate receptors (mGluRs) can induce acute depression of excitatory synaptic transmission and long-term depression (LTD) in area CA1 of the rat hippocampus. The underlying mechanisms for both forms of depression are unknown. By measuring presynaptic calcium transients, we show that a reduction in the stimulation-induced presynaptic calcium rise that triggers vesicular release causes the acute depression of transmission by group I mGluRs. In contrast, the mechanism underlying mGluR-induced LTD does not involve a persistent change in stimulation-induced calcium influx. However, analysis of paired-pulse facilitation experiments suggests a presynaptic location for expression of this form of LTD. Furthermore, we show that mGluR-induced LTD can be completely blocked by a specific mGluR5 antagonist, whereas mGluR1 antagonists strongly attenuate the acute depression of transmission. These results support the hypothesis that the acute depression of transmission caused by activation of group I mGluRs involves regulation of stimulation-induced presynaptic calcium transients, whereas mGluR-induced LTD involves a distinct presynaptic modulation downstream of calcium influx.
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收藏
页码：6885 / 6890
页数：6
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